| pubmed-article:2164939 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2164939 | lifeskim:mentions | umls-concept:C0013227 | lld:lifeskim |
| pubmed-article:2164939 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:2164939 | lifeskim:mentions | umls-concept:C0007765 | lld:lifeskim |
| pubmed-article:2164939 | lifeskim:mentions | umls-concept:C0064239 | lld:lifeskim |
| pubmed-article:2164939 | lifeskim:mentions | umls-concept:C0019409 | lld:lifeskim |
| pubmed-article:2164939 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2164939 | pubmed:dateCreated | 1990-8-29 | lld:pubmed |
| pubmed-article:2164939 | pubmed:abstractText | In guinea-pig cerebellum, saturation studies reveal that the nonselective opioid [3H]ethylketazocine has a binding capacity (R) of 6.79 pmol/g tissue which is similar to the sum of the individual R values of the mu-, delta- and kappa 1-selective opioids. Conversely, the binding parameters of the nonselective opioid [3H]bremazocine are best-fitted to a two-site model (Kd1 = 0.12 nM, R1 = 11.3 pmol/g tissue; Kd2 = 6.03 nM, R2 = 9.09 pmol/g tissue) with an R TOTAL value of 20.3 pmol/g tissue which is statistically different from the R value of [3H]ethylketazocine or the sum of R mu + R delta + R kappa 1. This suggests that [3H]bremazocine labels additional opioid binding sites. After suppression of the mu-, delta- and kappa 1-receptors, [3H]bremazocine binding is then best-fitted to a one-site model with a Kd value of 1.48 nM and an R value of 11.2 pmol/g tissue. Competition studies done against the binding of [3H]U69593 indicate that the opioid receptors labelled with this ligand are related to the kappa 1-receptor subtype. However, competition studies performed against the binding of [3H]bremazocine (under suppressed conditions) display a pharmacological profile related to another subtype of kappa-receptors previously described in guinea-pig brain as the kappa 2-receptors. | lld:pubmed |
| pubmed-article:2164939 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2164939 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2164939 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2164939 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2164939 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2164939 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2164939 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2164939 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2164939 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2164939 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2164939 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2164939 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2164939 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2164939 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2164939 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:2164939 | pubmed:author | pubmed-author:MagnanJJ | lld:pubmed |
| pubmed-article:2164939 | pubmed:author | pubmed-author:TiberiMM | lld:pubmed |
| pubmed-article:2164939 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2164939 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:2164939 | pubmed:volume | 188 | lld:pubmed |
| pubmed-article:2164939 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2164939 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2164939 | pubmed:pagination | 379-89 | lld:pubmed |
| pubmed-article:2164939 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2164939 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2164939 | pubmed:articleTitle | Demonstration of the heterogeneity of the kappa-opioid receptors in guinea-pig cerebellum using selective and nonselective drugs. | lld:pubmed |
| pubmed-article:2164939 | pubmed:affiliation | Département de pharmacologie, Université de Montréal, Quebec, Canada. | lld:pubmed |
| pubmed-article:2164939 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2164939 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2164939 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2164939 | lld:pubmed |
