| pubmed-article:2164927 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2164927 | lifeskim:mentions | umls-concept:C0043167 | lld:lifeskim |
| pubmed-article:2164927 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:2164927 | lifeskim:mentions | umls-concept:C0008354 | lld:lifeskim |
| pubmed-article:2164927 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:2164927 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2164927 | lifeskim:mentions | umls-concept:C0036770 | lld:lifeskim |
| pubmed-article:2164927 | lifeskim:mentions | umls-concept:C0733758 | lld:lifeskim |
| pubmed-article:2164927 | lifeskim:mentions | umls-concept:C0001492 | lld:lifeskim |
| pubmed-article:2164927 | lifeskim:mentions | umls-concept:C0596637 | lld:lifeskim |
| pubmed-article:2164927 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:2164927 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:2164927 | lifeskim:mentions | umls-concept:C1546856 | lld:lifeskim |
| pubmed-article:2164927 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2164927 | pubmed:dateCreated | 1990-8-30 | lld:pubmed |
| pubmed-article:2164927 | pubmed:abstractText | We have previously reported that FSH stimulates flux of 45Ca2+ into cultured Sertoli cells from immature rats via voltage-sensitive and voltage-independent calcium channels. In the present study, we show that this effect of FSH does not require cholera toxin (CT)- or pertussis toxin (PT)-sensitive guanine nucleotide binding (G) protein or activation of adenylate cyclase (AC). Significant stimulation of 45Ca2+ influx was observed within 1 min, and maximal response (3.2-fold over basal levels) was achieved within 2 min after exposure to FSH. FSH-stimulated elevations in cellular cAMP paralleled increases in 45Ca2+ uptake, suggesting a possible coupling of AC activation to 45Ca2+ influx. (Bu)2cAMP, however, was not able to enhance 45Ca2+ uptake over basal levels at a final concentration of 1000 microM, although a concentration-related increase in androstenedione conversion to estradiol was evident. Exposure of Sertoli cells to CT (10 ng/ml) consistently stimulated basal levels of androstenedione conversion to estradiol but had no effect on basal levels of 45Ca2+ uptake. Similarly, CT had no effect on FSH-induced 45Ca2+ uptake, but potentiated FSH-stimulated estradiol synthesis. PT (10 ng/ml) augmented basal and FSH-stimulated estradiol secretion without affecting 45Ca2+ influx. The adenosine analog N6-phenylisopropyladenosine, which binds to Gi-coupled adenosine receptors on Sertoli cells, inhibited FSH-stimulated androgen conversion to estradiol in a dose-related (1-1000 nM) manner, but FSH-stimulated 45Ca2+ influx remained unchanged. Our results show that in contrast to FSH-stimulated estradiol synthesis, the flux of 45Ca2+ into Sertoli cells in response to FSH is not mediated either directly or indirectly by CT- or PT-sensitive G protein, nor does it require activation of AC. Our data further suggest that the FSH receptor itself may function as a calcium channel. | lld:pubmed |
| pubmed-article:2164927 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2164927 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2164927 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2164927 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2164927 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2164927 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2164927 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2164927 | pubmed:issn | 0013-7227 | lld:pubmed |
| pubmed-article:2164927 | pubmed:author | pubmed-author:ReichertL... | lld:pubmed |
| pubmed-article:2164927 | pubmed:author | pubmed-author:GrassoPP | lld:pubmed |
| pubmed-article:2164927 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2164927 | pubmed:volume | 127 | lld:pubmed |
| pubmed-article:2164927 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2164927 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2164927 | pubmed:pagination | 949-56 | lld:pubmed |
| pubmed-article:2164927 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2164927 | pubmed:meshHeading | pubmed-meshheading:2164927-... | lld:pubmed |
| pubmed-article:2164927 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2164927 | pubmed:articleTitle | Follicle-stimulating hormone receptor-mediated uptake of 45Ca2+ by cultured rat Sertoli cells does not require activation of cholera toxin- or pertussis toxin-sensitive guanine nucleotide binding proteins or adenylate cyclase. | lld:pubmed |
| pubmed-article:2164927 | pubmed:affiliation | Department of Biochemistry, Albany Medical College, New York 12208. | lld:pubmed |
| pubmed-article:2164927 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2164927 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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