| pubmed-article:21647421 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21647421 | lifeskim:mentions | umls-concept:C0034067 | lld:lifeskim |
| pubmed-article:21647421 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:21647421 | lifeskim:mentions | umls-concept:C0271510 | lld:lifeskim |
| pubmed-article:21647421 | lifeskim:mentions | umls-concept:C0239059 | lld:lifeskim |
| pubmed-article:21647421 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:21647421 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:21647421 | lifeskim:mentions | umls-concept:C1337092 | lld:lifeskim |
| pubmed-article:21647421 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:21647421 | lifeskim:mentions | umls-concept:C1825593 | lld:lifeskim |
| pubmed-article:21647421 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:21647421 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:21647421 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:21647421 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:21647421 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:21647421 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:21647421 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:21647421 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:21647421 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:21647421 | pubmed:dateCreated | 2011-6-7 | lld:pubmed |
| pubmed-article:21647421 | pubmed:abstractText | Chronic Obstructive Pulmonary Disease (COPD) is characterized by airspace enlargement and peribronchial lymphoid follicles; however, the immunological mechanisms leading to these pathologic changes remain undefined. Here we show that cigarette smoke is a selective adjuvant that augments in vitro and in vivo Th17, but not Th1, cell differentiation via the aryl hydrocarbon receptor. Smoke exposed IL-17RA(-/-) mice failed to induce CCL2 and MMP12 compared to WT mice. Remarkably, in contrast to WT mice, IL-17RA(-/-) mice failed to develop emphysema after 6 months of cigarette smoke exposure. Taken together, these data demonstrate that cigarette smoke is a potent Th17 adjuvant and that IL-17RA signaling is required for chemokine expression necessary for MMP12 induction and tissue emphysema. | lld:pubmed |
| pubmed-article:21647421 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21647421 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21647421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21647421 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21647421 | pubmed:issn | 1932-6203 | lld:pubmed |
| pubmed-article:21647421 | pubmed:author | pubmed-author:KollsJay KJK | lld:pubmed |
| pubmed-article:21647421 | pubmed:author | pubmed-author:ShapiroSteven... | lld:pubmed |
| pubmed-article:21647421 | pubmed:author | pubmed-author:PociaskDerek... | lld:pubmed |
| pubmed-article:21647421 | pubmed:author | pubmed-author:ZhengMingquan... | lld:pubmed |
| pubmed-article:21647421 | pubmed:author | pubmed-author:KeyserMatthew... | lld:pubmed |
| pubmed-article:21647421 | pubmed:author | pubmed-author:AlcornJohn... | lld:pubmed |
| pubmed-article:21647421 | pubmed:author | pubmed-author:KongChenC | lld:pubmed |
| pubmed-article:21647421 | pubmed:author | pubmed-author:HoughtonA... | lld:pubmed |
| pubmed-article:21647421 | pubmed:author | pubmed-author:McAleerJeremy... | lld:pubmed |
| pubmed-article:21647421 | pubmed:author | pubmed-author:KreindlerJame... | lld:pubmed |
| pubmed-article:21647421 | pubmed:author | pubmed-author:ChanYvonne... | lld:pubmed |
| pubmed-article:21647421 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21647421 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:21647421 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21647421 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21647421 | pubmed:pagination | e20333 | lld:pubmed |
| pubmed-article:21647421 | pubmed:meshHeading | pubmed-meshheading:21647421... | lld:pubmed |
| pubmed-article:21647421 | pubmed:meshHeading | pubmed-meshheading:21647421... | lld:pubmed |
| pubmed-article:21647421 | pubmed:meshHeading | pubmed-meshheading:21647421... | lld:pubmed |
| pubmed-article:21647421 | pubmed:meshHeading | pubmed-meshheading:21647421... | lld:pubmed |
| pubmed-article:21647421 | pubmed:meshHeading | pubmed-meshheading:21647421... | lld:pubmed |
| pubmed-article:21647421 | pubmed:meshHeading | pubmed-meshheading:21647421... | lld:pubmed |
| pubmed-article:21647421 | pubmed:meshHeading | pubmed-meshheading:21647421... | lld:pubmed |
| pubmed-article:21647421 | pubmed:meshHeading | pubmed-meshheading:21647421... | lld:pubmed |
| pubmed-article:21647421 | pubmed:meshHeading | pubmed-meshheading:21647421... | lld:pubmed |
| pubmed-article:21647421 | pubmed:meshHeading | pubmed-meshheading:21647421... | lld:pubmed |
| pubmed-article:21647421 | pubmed:meshHeading | pubmed-meshheading:21647421... | lld:pubmed |
| pubmed-article:21647421 | pubmed:meshHeading | pubmed-meshheading:21647421... | lld:pubmed |
| pubmed-article:21647421 | pubmed:meshHeading | pubmed-meshheading:21647421... | lld:pubmed |
| pubmed-article:21647421 | pubmed:meshHeading | pubmed-meshheading:21647421... | lld:pubmed |
| pubmed-article:21647421 | pubmed:meshHeading | pubmed-meshheading:21647421... | lld:pubmed |
