| pubmed-article:2163435 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2163435 | lifeskim:mentions | umls-concept:C0034374 | lld:lifeskim |
| pubmed-article:2163435 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:2163435 | lifeskim:mentions | umls-concept:C0040995 | lld:lifeskim |
| pubmed-article:2163435 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:2163435 | lifeskim:mentions | umls-concept:C0032821 | lld:lifeskim |
| pubmed-article:2163435 | lifeskim:mentions | umls-concept:C0037473 | lld:lifeskim |
| pubmed-article:2163435 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:2163435 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:2163435 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2163435 | pubmed:dateCreated | 1990-8-8 | lld:pubmed |
| pubmed-article:2163435 | pubmed:abstractText | Whole-cell voltage clamp and single-channel recordings were performed on cultured trigeminal ganglion neurons from quail embryos in order to study a sodium-activated potassium current (KNa). When KNa was activated by a step depolarization in voltage clamp, there was a proportionality between KNa and INa at all voltages between the threshold of INa and ENa. Single-channel recordings indicated that KNa could be activated already by 12 mM intracellular sodium and was almost fully activated at 50 mM sodium. 100 mM lithium, 100 mM choline, or 5 microM calcium did not activate KNa. The relationship between the probability for the channel to be open (Po) vs. the sodium concentration and the relationship of KNa open time-distributions vs. the sodium concentration suggest that two to three sodium ions bind cooperatively before KNa channels open. KNa channels were sensitive to depolarization; at 12 mM sodium, a 42-mV depolarization caused an e-fold increase in Po. Under physiological conditions, the conductance of the KNa channel was 50 pS. This conductance increased to 174 pS when the intra- and extracellular potassium concentrations were 75 and 150 mM, respectively. | lld:pubmed |
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| pubmed-article:2163435 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2163435 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2163435 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2163435 | pubmed:month | May | lld:pubmed |
| pubmed-article:2163435 | pubmed:issn | 0022-1295 | lld:pubmed |
| pubmed-article:2163435 | pubmed:author | pubmed-author:BertrandDD | lld:pubmed |
| pubmed-article:2163435 | pubmed:author | pubmed-author:BaderC RCR | lld:pubmed |
| pubmed-article:2163435 | pubmed:author | pubmed-author:HaimannCC | lld:pubmed |
| pubmed-article:2163435 | pubmed:author | pubmed-author:BernheimLL | lld:pubmed |
| pubmed-article:2163435 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2163435 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:2163435 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2163435 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2163435 | pubmed:pagination | 961-79 | lld:pubmed |
| pubmed-article:2163435 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2163435 | pubmed:meshHeading | pubmed-meshheading:2163435-... | lld:pubmed |
| pubmed-article:2163435 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2163435 | pubmed:articleTitle | Potassium current activated by intracellular sodium in quail trigeminal ganglion neurons. | lld:pubmed |
| pubmed-article:2163435 | pubmed:affiliation | Department of Physiology, Hôpital Cantonal Universitaire, Geneva, Switzerland. | lld:pubmed |
| pubmed-article:2163435 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2163435 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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