| pubmed-article:21628563 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21628563 | lifeskim:mentions | umls-concept:C1882071 | lld:lifeskim |
| pubmed-article:21628563 | lifeskim:mentions | umls-concept:C0017636 | lld:lifeskim |
| pubmed-article:21628563 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:21628563 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:21628563 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:21628563 | lifeskim:mentions | umls-concept:C0183683 | lld:lifeskim |
| pubmed-article:21628563 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:21628563 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:21628563 | pubmed:dateCreated | 2011-6-15 | lld:pubmed |
| pubmed-article:21628563 | pubmed:abstractText | The tyrosine kinase c-Met promotes the formation and malignant progression of multiple cancers. It is well known that c-Met hyperactivation increases tumorigenicity and tumor cell resistance to DNA damaging agents, properties associated with tumor-initiating stem cells. However, a link between c-Met signaling and the formation and/or maintenance of neoplastic stem cells has not been previously identified. Here, we show that c-Met is activated and functional in glioblastoma (GBM) neurospheres enriched for glioblastoma tumor-initiating stem cells and that c-Met expression/function correlates with stem cell marker expression and the neoplastic stem cell phenotype in glioblastoma neurospheres and clinical glioblastoma specimens. c-Met activation was found to induce the expression of reprogramming transcription factors (RFs) known to support embryonic stem cells and induce differentiated cells to form pluripotent stem (iPS) cells, and c-Met activation counteracted the effects of forced differentiation in glioblastoma neurospheres. Expression of the reprogramming transcription factor Nanog by glioblastoma cells is shown to mediate the ability of c-Met to induce the stem cell characteristics of neurosphere formation and neurosphere cell self-renewal. These findings show that c-Met enhances the population of glioblastoma stem cells (GBM SCs) via a mechanism requiring Nanog and potentially other c-Met-responsive reprogramming transcription factors. | lld:pubmed |
| pubmed-article:21628563 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21628563 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21628563 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21628563 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21628563 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21628563 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21628563 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21628563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21628563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21628563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21628563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21628563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21628563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21628563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21628563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21628563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21628563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21628563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21628563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21628563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21628563 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21628563 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:21628563 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:21628563 | pubmed:author | pubmed-author:LalBachchuB | lld:pubmed |
| pubmed-article:21628563 | pubmed:author | pubmed-author:LaterraJohnJ | lld:pubmed |
| pubmed-article:21628563 | pubmed:author | pubmed-author:XiaShuliS | lld:pubmed |
| pubmed-article:21628563 | pubmed:author | pubmed-author:EberhartCharl... | lld:pubmed |
| pubmed-article:21628563 | pubmed:author | pubmed-author:AngelaLiL | lld:pubmed |
| pubmed-article:21628563 | pubmed:author | pubmed-author:LiYunqingY | lld:pubmed |
| pubmed-article:21628563 | pubmed:author | pubmed-author:SangYingyingY | lld:pubmed |
| pubmed-article:21628563 | pubmed:author | pubmed-author:Quiñones-Hino... | lld:pubmed |
| pubmed-article:21628563 | pubmed:author | pubmed-author:GlasMartinM | lld:pubmed |
| pubmed-article:21628563 | pubmed:author | pubmed-author:SchefflerBjor... | lld:pubmed |
| pubmed-article:21628563 | pubmed:author | pubmed-author:YingMingyaoM | lld:pubmed |
| pubmed-article:21628563 | pubmed:author | pubmed-author:Guerrero-Cáza... | lld:pubmed |
| pubmed-article:21628563 | pubmed:author | pubmed-author:TrageserDanie... | lld:pubmed |
| pubmed-article:21628563 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21628563 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:21628563 | pubmed:volume | 108 | lld:pubmed |
| pubmed-article:21628563 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21628563 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21628563 | pubmed:pagination | 9951-6 | lld:pubmed |
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| pubmed-article:21628563 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21628563 | pubmed:articleTitle | c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype. | lld:pubmed |
| pubmed-article:21628563 | pubmed:affiliation | Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, MD 21205, USA. LiYu@kennedykrieger.org | lld:pubmed |
| pubmed-article:21628563 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21628563 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21628563 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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