| pubmed-article:21624953 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21624953 | lifeskim:mentions | umls-concept:C0014257 | lld:lifeskim |
| pubmed-article:21624953 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:21624953 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:21624953 | lifeskim:mentions | umls-concept:C0031164 | lld:lifeskim |
| pubmed-article:21624953 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:21624953 | lifeskim:mentions | umls-concept:C1328815 | lld:lifeskim |
| pubmed-article:21624953 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:21624953 | pubmed:dateCreated | 2011-5-31 | lld:pubmed |
| pubmed-article:21624953 | pubmed:abstractText | Endothelial barrier function is regulated by adherens junctions (AJs) and caveolae-mediated transcellular pathways. The opening of AJs that is observed in caveolin-1(-/-) (Cav-1(-/-)) endothelium suggests that Cav-1 is necessary for AJ assembly or maintenance. Here, using endothelial cells isolated from Cav-1(-/-) mice, we show that Cav-1 deficiency induced the activation of endothelial nitric oxide synthase (eNOS) and the generation of nitric oxide (NO) and peroxynitrite. We assessed S-nitrosylation and nitration of AJ-associated proteins to identify downstream NO redox signaling targets. We found that the GTPase-activating protein (GAP) p190RhoGAP-A was selectively nitrated at Tyr1105, resulting in impaired GAP activity and RhoA activation. Inhibition of eNOS or RhoA restored AJ integrity and diminished endothelial hyperpermeability in Cav-1(-/-) mice. Thrombin, a mediator of increased endothelial permeability, also induced nitration of p120-catenin-associated p190RhoGAP-A. Thus, eNOS-dependent nitration of p190RhoGAP-A represents a crucial mechanism for AJ disassembly and resultant increased endothelial permeability. | lld:pubmed |
| pubmed-article:21624953 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21624953 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21624953 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21624953 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21624953 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21624953 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21624953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21624953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21624953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21624953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21624953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21624953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21624953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21624953 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21624953 | pubmed:month | May | lld:pubmed |
| pubmed-article:21624953 | pubmed:issn | 1540-8140 | lld:pubmed |
| pubmed-article:21624953 | pubmed:author | pubmed-author:MalikAsrar... | lld:pubmed |
| pubmed-article:21624953 | pubmed:author | pubmed-author:VogelStephen... | lld:pubmed |
| pubmed-article:21624953 | pubmed:author | pubmed-author:BrovkovychVik... | lld:pubmed |
| pubmed-article:21624953 | pubmed:author | pubmed-author:BoniniMarcelo... | lld:pubmed |
| pubmed-article:21624953 | pubmed:author | pubmed-author:ZhaoYou-YangY... | lld:pubmed |
| pubmed-article:21624953 | pubmed:author | pubmed-author:KomarovaYulia... | lld:pubmed |
| pubmed-article:21624953 | pubmed:author | pubmed-author:GaoXiaopeiX | lld:pubmed |
| pubmed-article:21624953 | pubmed:author | pubmed-author:RajasinghJohn... | lld:pubmed |
| pubmed-article:21624953 | pubmed:author | pubmed-author:SiddiquiM... | lld:pubmed |
| pubmed-article:21624953 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21624953 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:21624953 | pubmed:volume | 193 | lld:pubmed |
| pubmed-article:21624953 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21624953 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21624953 | pubmed:pagination | 841-50 | lld:pubmed |
| pubmed-article:21624953 | pubmed:meshHeading | pubmed-meshheading:21624953... | lld:pubmed |
| pubmed-article:21624953 | pubmed:meshHeading | pubmed-meshheading:21624953... | lld:pubmed |
| pubmed-article:21624953 | pubmed:meshHeading | pubmed-meshheading:21624953... | lld:pubmed |
| pubmed-article:21624953 | pubmed:meshHeading | pubmed-meshheading:21624953... | lld:pubmed |
| pubmed-article:21624953 | pubmed:meshHeading | pubmed-meshheading:21624953... | lld:pubmed |
| pubmed-article:21624953 | pubmed:meshHeading | pubmed-meshheading:21624953... | lld:pubmed |
| pubmed-article:21624953 | pubmed:meshHeading | pubmed-meshheading:21624953... | lld:pubmed |
| pubmed-article:21624953 | pubmed:meshHeading | pubmed-meshheading:21624953... | lld:pubmed |
| pubmed-article:21624953 | pubmed:meshHeading | pubmed-meshheading:21624953... | lld:pubmed |
| pubmed-article:21624953 | pubmed:meshHeading | pubmed-meshheading:21624953... | lld:pubmed |
| pubmed-article:21624953 | pubmed:meshHeading | pubmed-meshheading:21624953... | lld:pubmed |
| pubmed-article:21624953 | pubmed:meshHeading | pubmed-meshheading:21624953... | lld:pubmed |
| pubmed-article:21624953 | pubmed:meshHeading | pubmed-meshheading:21624953... | lld:pubmed |
| pubmed-article:21624953 | pubmed:meshHeading | pubmed-meshheading:21624953... | lld:pubmed |
| pubmed-article:21624953 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21624953 | pubmed:articleTitle | Caveolin-1-eNOS signaling promotes p190RhoGAP-A nitration and endothelial permeability. | lld:pubmed |
| pubmed-article:21624953 | pubmed:affiliation | Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA. | lld:pubmed |
| pubmed-article:21624953 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21624953 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21624953 | lld:entrezgene |
