| pubmed-article:21620529 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21620529 | lifeskim:mentions | umls-concept:C1261322 | lld:lifeskim |
| pubmed-article:21620529 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:21620529 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:21620529 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:21620529 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:21620529 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:21620529 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:21620529 | lifeskim:mentions | umls-concept:C0887820 | lld:lifeskim |
| pubmed-article:21620529 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:21620529 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:21620529 | pubmed:dateCreated | 2011-6-13 | lld:pubmed |
| pubmed-article:21620529 | pubmed:abstractText | From the anti-tumor active N-tryptophanyl-?-carboline-3-carboxylic acid benzyl ester and ?-carboline-3-carbonyltryptophan benzyl ester, a pharmacophore, Trp-Trp-OBzl, was drawn. Based on the DOCK scores amino acid residue was inserted into the C-terminus of Trp-Trp-OBzl and twenty Trp-Trp-AA-OBzls (AA = amino acid residues) were provided as DNA intercalators. On the in vitro and in vivo models seventeen Trp-Trp-AA-OBzls were anti-tumor active, and twelve Trp-Trp-AA-OBzls were more active than cytarabine. In acute toxicity assay Trp-Trp-AA-OBzls did not damage the immunologic function and had an LD(50) of more than 500 mg/kg. The relationships of structure and activity were analyzed with 3D QSAR. The action mechanism studies revealed that the in vivo anti-tumor action of Trp-Trp-AA-OBzls was the result of DNA intercalation. | lld:pubmed |
| pubmed-article:21620529 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21620529 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21620529 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21620529 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21620529 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21620529 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21620529 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21620529 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21620529 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21620529 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21620529 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21620529 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21620529 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:21620529 | pubmed:issn | 1768-3254 | lld:pubmed |
| pubmed-article:21620529 | pubmed:author | pubmed-author:XXX | lld:pubmed |
| pubmed-article:21620529 | pubmed:author | pubmed-author:ZhaoMingM | lld:pubmed |
| pubmed-article:21620529 | pubmed:author | pubmed-author:PengShiqiS | lld:pubmed |
| pubmed-article:21620529 | pubmed:author | pubmed-author:YangYifanY | lld:pubmed |
| pubmed-article:21620529 | pubmed:author | pubmed-author:WangYujiY | lld:pubmed |
| pubmed-article:21620529 | pubmed:author | pubmed-author:WuJianhuiJ | lld:pubmed |
| pubmed-article:21620529 | pubmed:author | pubmed-author:ZhangXiaoyiX | lld:pubmed |
| pubmed-article:21620529 | pubmed:author | pubmed-author:ZhengMeiqingM | lld:pubmed |
| pubmed-article:21620529 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Masson SAS. All rights reserved. | lld:pubmed |
| pubmed-article:21620529 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21620529 | pubmed:volume | 46 | lld:pubmed |
| pubmed-article:21620529 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21620529 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21620529 | pubmed:pagination | 3410-9 | lld:pubmed |
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| pubmed-article:21620529 | pubmed:meshHeading | pubmed-meshheading:21620529... | lld:pubmed |
| pubmed-article:21620529 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21620529 | pubmed:articleTitle | A class of Trp-Trp-AA-OBzl: Synthesis, in vitro anti-proliferation/in vivo anti-tumor evaluation, intercalation-mechanism investigation and 3D QSAR analysis. | lld:pubmed |
| pubmed-article:21620529 | pubmed:affiliation | College of Pharmaceutical Sciences, Capital Medical University, No. 10, Beijing 100069, PR China. | lld:pubmed |
| pubmed-article:21620529 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21620529 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:21620529 | lld:chembl |
