| pubmed-article:21609895 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21609895 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:21609895 | lifeskim:mentions | umls-concept:C0740457 | lld:lifeskim |
| pubmed-article:21609895 | lifeskim:mentions | umls-concept:C0254610 | lld:lifeskim |
| pubmed-article:21609895 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:21609895 | lifeskim:mentions | umls-concept:C1704735 | lld:lifeskim |
| pubmed-article:21609895 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:21609895 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:21609895 | pubmed:dateCreated | 2011-6-7 | lld:pubmed |
| pubmed-article:21609895 | pubmed:abstractText | Primary human epithelial renal cells of normal (HRE), paratumoral (pTEC) and tumoral (RCC) origin display important differences, concerning the expression and biological effects of the IL-15/IL-15R system that deeply influences the evolution of the tumour microenvironment. A major distinguishing feature is represented in RCC and pTEC by the loss of the ?c chain leading to the assembly of a IL-15R?? heterodimer that in response to physiologic concentrations of IL-15 initiates the process of their epithelial-mesenchymal transition (EMT). In contrast, this treatment in HRE cells, which display the IL-15R???c heterotrimer, causes opposite effects inhibiting their drift towards EMT. Thus, IL-15 at physiologic concentrations displays novel functions acting as a major regulator of renal epithelial homeostasis. As second distinguishing feature, RCC and pTEC but not HRE cells express a trans-membrane-bound IL-15 (tmb-IL-15) able to deliver a reverse signal in response to the soluble IL-15R? chain inducing their EMT. In conclusion, comparison of primary normal (HRE) to primary pathological cells (pTEC and RCC) highlights two major issues: (1) IL-15 is a major regulator of epithelial homeostasis; (2) "apparently normal" pTEC cells, could contribute to organize a generalized "pre-neoplastic" environment committed to favour tumour progression. | lld:pubmed |
| pubmed-article:21609895 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21609895 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21609895 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21609895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21609895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21609895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21609895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21609895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21609895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21609895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21609895 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21609895 | pubmed:month | May | lld:pubmed |
| pubmed-article:21609895 | pubmed:issn | 1769-6917 | lld:pubmed |
| pubmed-article:21609895 | pubmed:author | pubmed-author:Giron-MichelJ... | lld:pubmed |
| pubmed-article:21609895 | pubmed:author | pubmed-author:AzzaroneBruno... | lld:pubmed |
| pubmed-article:21609895 | pubmed:author | pubmed-author:ChouaibSalemS | lld:pubmed |
| pubmed-article:21609895 | pubmed:author | pubmed-author:CaignardAnneA | lld:pubmed |
| pubmed-article:21609895 | pubmed:author | pubmed-author:EidPierreP | lld:pubmed |
| pubmed-article:21609895 | pubmed:author | pubmed-author:DevocelleAuro... | lld:pubmed |
| pubmed-article:21609895 | pubmed:author | pubmed-author:PerrierAureli... | lld:pubmed |
| pubmed-article:21609895 | pubmed:author | pubmed-author:KhawamKrystel... | lld:pubmed |
| pubmed-article:21609895 | pubmed:author | pubmed-author:AzziSandyS | lld:pubmed |
| pubmed-article:21609895 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21609895 | pubmed:volume | 98 | lld:pubmed |
| pubmed-article:21609895 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21609895 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21609895 | pubmed:pagination | 32-9 | lld:pubmed |
| pubmed-article:21609895 | pubmed:meshHeading | pubmed-meshheading:21609895... | lld:pubmed |
| pubmed-article:21609895 | pubmed:meshHeading | pubmed-meshheading:21609895... | lld:pubmed |
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| pubmed-article:21609895 | pubmed:meshHeading | pubmed-meshheading:21609895... | lld:pubmed |
| pubmed-article:21609895 | pubmed:meshHeading | pubmed-meshheading:21609895... | lld:pubmed |
| pubmed-article:21609895 | pubmed:meshHeading | pubmed-meshheading:21609895... | lld:pubmed |
| pubmed-article:21609895 | pubmed:meshHeading | pubmed-meshheading:21609895... | lld:pubmed |
| pubmed-article:21609895 | pubmed:meshHeading | pubmed-meshheading:21609895... | lld:pubmed |
| pubmed-article:21609895 | pubmed:meshHeading | pubmed-meshheading:21609895... | lld:pubmed |
| pubmed-article:21609895 | pubmed:meshHeading | pubmed-meshheading:21609895... | lld:pubmed |
| pubmed-article:21609895 | pubmed:meshHeading | pubmed-meshheading:21609895... | lld:pubmed |
| pubmed-article:21609895 | pubmed:meshHeading | pubmed-meshheading:21609895... | lld:pubmed |
| pubmed-article:21609895 | pubmed:meshHeading | pubmed-meshheading:21609895... | lld:pubmed |
| pubmed-article:21609895 | pubmed:meshHeading | pubmed-meshheading:21609895... | lld:pubmed |
| pubmed-article:21609895 | pubmed:meshHeading | pubmed-meshheading:21609895... | lld:pubmed |
| pubmed-article:21609895 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21609895 | pubmed:articleTitle | Interleukin-15 is a major regulator of the cell-microenvironment interactions in human renal cancer. | lld:pubmed |
| pubmed-article:21609895 | pubmed:affiliation | Hôpital Paul-Brousse, université de Paris-Sud, Inserm UMR 1014, 14, avenue Paul-Vaillant-Couturier, 94807 Villejuif Cedex, France. | lld:pubmed |
| pubmed-article:21609895 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21609895 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
