| pubmed-article:2160837 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2160837 | lifeskim:mentions | umls-concept:C0597694 | lld:lifeskim |
| pubmed-article:2160837 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:2160837 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:2160837 | lifeskim:mentions | umls-concept:C0043481 | lld:lifeskim |
| pubmed-article:2160837 | lifeskim:mentions | umls-concept:C0079883 | lld:lifeskim |
| pubmed-article:2160837 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2160837 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2160837 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:2160837 | lifeskim:mentions | umls-concept:C1521805 | lld:lifeskim |
| pubmed-article:2160837 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2160837 | pubmed:dateCreated | 1990-7-5 | lld:pubmed |
| pubmed-article:2160837 | pubmed:abstractText | Pharmacological characterization of Zn2+ effects on glutamate ionotropic receptors was investigated in Xenopus oocytes injected with rat brain mRNA, using a double microelectrode, voltage-clamp technique. At low concentration, Zn2+ inhibited NMDA currents (IC50 = 42.9 +/- 1.3 microM) and potentiated both AMPA (EC50 = 30.0 +/- 1.2 microM) and desensitized kainate responses (EC50 = 13.0 +/- 0.1 microM). At higher concentrations, Zn2+ inhibited non-NMDA responses with IC50 values of 1.3 +/- 0.1 mM and 1.2 +/- 0.3 mM for AMPA and kainate, respectively. The potentiation of AMPA or quisqualate currents by Zn2+ was more than 2-fold, whereas that of the kainate current was only close to 30%. This potentiating effect of Zn2+ on AMPA current modified neither the affinity of the agonist for its site nor the current-voltage relationship. In addition, 500 microM Zn2+ differentially affected NMDA and non-NMDA components of the glutamate-induced response. The possible physiological relevance of Zn2+ modulation is discussed. | lld:pubmed |
| pubmed-article:2160837 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2160837 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2160837 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2160837 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2160837 | pubmed:month | May | lld:pubmed |
| pubmed-article:2160837 | pubmed:issn | 0896-6273 | lld:pubmed |
| pubmed-article:2160837 | pubmed:author | pubmed-author:NargeotJJ | lld:pubmed |
| pubmed-article:2160837 | pubmed:author | pubmed-author:MuhrC ECE | lld:pubmed |
| pubmed-article:2160837 | pubmed:author | pubmed-author:LinF XFX | lld:pubmed |
| pubmed-article:2160837 | pubmed:author | pubmed-author:RassendrenF... | lld:pubmed |
| pubmed-article:2160837 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2160837 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:2160837 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2160837 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2160837 | pubmed:pagination | 733-40 | lld:pubmed |
| pubmed-article:2160837 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2160837 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2160837 | pubmed:articleTitle | Zinc has opposite effects on NMDA and non-NMDA receptors expressed in Xenopus oocytes. | lld:pubmed |
| pubmed-article:2160837 | pubmed:affiliation | CNRS UPR 8402, INSERM U249, Université Montpellier I, France. | lld:pubmed |
| pubmed-article:2160837 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2160837 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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