| pubmed-article:21600876 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21600876 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:21600876 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:21600876 | lifeskim:mentions | umls-concept:C2699153 | lld:lifeskim |
| pubmed-article:21600876 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:21600876 | lifeskim:mentions | umls-concept:C1269955 | lld:lifeskim |
| pubmed-article:21600876 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:21600876 | lifeskim:mentions | umls-concept:C0600210 | lld:lifeskim |
| pubmed-article:21600876 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:21600876 | pubmed:dateCreated | 2011-6-13 | lld:pubmed |
| pubmed-article:21600876 | pubmed:abstractText | MicroRNAs (miRNA) regulate expression of several genes associated with human cancer. Here, we analyzed the function of miR-34c, an effector of p53, in cervical carcinoma cells. Expression of either miR-34c-3p or miR-34c-5p mimics caused inhibition of cell proliferation in the HPV-containing SiHa cells but not in other cervical cells irrespective of tumorigenicity and HPV content. These results suggest that SiHa cells may lack of regulatory mechanisms for miR-34c. Monolayer proliferation results showed that miR-34c-3p produced a more pronounced inhibitory effect although both miRNAs caused inhibition of anchorage independent growth at similar extent. However, ectopic expression of pre-miR-34c-3p, but not pre-miR-34c-5p, caused S-phase arrest in SiHa cells triggering a strong dose-dependent apoptosis. A significant inhibition was observed only for miR-34c-3p on SiHa cells migration and invasion, therefore implying alternative regulatory pathways and targets. These results suggest differential tumor suppressor roles for miR-34c-3p and miR-34c-5p and provide new insights in the understanding of miRNA biology. | lld:pubmed |
| pubmed-article:21600876 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21600876 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21600876 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21600876 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21600876 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21600876 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21600876 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:21600876 | pubmed:issn | 1090-2104 | lld:pubmed |
| pubmed-article:21600876 | pubmed:author | pubmed-author:Alvarez-Salas... | lld:pubmed |
| pubmed-article:21600876 | pubmed:author | pubmed-author:LópezJesús... | lld:pubmed |
| pubmed-article:21600876 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:21600876 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21600876 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:21600876 | pubmed:volume | 409 | lld:pubmed |
| pubmed-article:21600876 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21600876 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21600876 | pubmed:pagination | 513-9 | lld:pubmed |
| pubmed-article:21600876 | pubmed:meshHeading | pubmed-meshheading:21600876... | lld:pubmed |
| pubmed-article:21600876 | pubmed:meshHeading | pubmed-meshheading:21600876... | lld:pubmed |
| pubmed-article:21600876 | pubmed:meshHeading | pubmed-meshheading:21600876... | lld:pubmed |
| pubmed-article:21600876 | pubmed:meshHeading | pubmed-meshheading:21600876... | lld:pubmed |
| pubmed-article:21600876 | pubmed:meshHeading | pubmed-meshheading:21600876... | lld:pubmed |
| pubmed-article:21600876 | pubmed:meshHeading | pubmed-meshheading:21600876... | lld:pubmed |
| pubmed-article:21600876 | pubmed:meshHeading | pubmed-meshheading:21600876... | lld:pubmed |
| pubmed-article:21600876 | pubmed:meshHeading | pubmed-meshheading:21600876... | lld:pubmed |
| pubmed-article:21600876 | pubmed:meshHeading | pubmed-meshheading:21600876... | lld:pubmed |
| pubmed-article:21600876 | pubmed:meshHeading | pubmed-meshheading:21600876... | lld:pubmed |
| pubmed-article:21600876 | pubmed:meshHeading | pubmed-meshheading:21600876... | lld:pubmed |
| pubmed-article:21600876 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21600876 | pubmed:articleTitle | Differential effects of miR-34c-3p and miR-34c-5p on SiHa cells proliferation apoptosis, migration and invasion. | lld:pubmed |
| pubmed-article:21600876 | pubmed:affiliation | Laboratorio de Terapia Génica, Departamento de Genética y Biología Molecular, CINVESTAV, Av. IPN 2508, México 07360 DF, Mexico. | lld:pubmed |
| pubmed-article:21600876 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21600876 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:407042 | entrezgene:pubmed | pubmed-article:21600876 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21600876 | lld:entrezgene |
