| pubmed-article:2159827 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2159827 | lifeskim:mentions | umls-concept:C1325529 | lld:lifeskim |
| pubmed-article:2159827 | lifeskim:mentions | umls-concept:C0037492 | lld:lifeskim |
| pubmed-article:2159827 | lifeskim:mentions | umls-concept:C0022702 | lld:lifeskim |
| pubmed-article:2159827 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:2159827 | lifeskim:mentions | umls-concept:C0597329 | lld:lifeskim |
| pubmed-article:2159827 | lifeskim:mentions | umls-concept:C0038078 | lld:lifeskim |
| pubmed-article:2159827 | lifeskim:mentions | umls-concept:C1554963 | lld:lifeskim |
| pubmed-article:2159827 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:2159827 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2159827 | pubmed:dateCreated | 1990-6-21 | lld:pubmed |
| pubmed-article:2159827 | pubmed:abstractText | The kinetics of sodium channel activation and inactivation were analyzed in the squid giant axons internally treated with various pyrethroids. Pyrethroids increased the steady-state sodium current in squid giant axons by removing the inactivation. The steady-state sodium conductances in control and pyrethroid-treated axons showed the same voltage dependence, indicating that the removal of inactivation by pyrethroids did not lead to an alteration of gating charge transfer. The pyrethroid-modified sodium channels were activated with a biphasic time course involving the movement of at least two gating particles, and both components were voltage-dependent. The slower component was abolished by treatment with either pronase or N-bromoacetamide. The net elementary charges transported in the electric membrane field were reduced in the course of slow activation of the pyrethroid-induced sodium current. It appears that the 'immobilization' of gating charge is related to the slow activation rather than the inactivation of the sodium channel. | lld:pubmed |
| pubmed-article:2159827 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2159827 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2159827 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2159827 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2159827 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2159827 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2159827 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2159827 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2159827 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2159827 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:2159827 | pubmed:author | pubmed-author:NarahashiTT | lld:pubmed |
| pubmed-article:2159827 | pubmed:author | pubmed-author:BrownL DLD | lld:pubmed |
| pubmed-article:2159827 | pubmed:author | pubmed-author:de WeilleJ... | lld:pubmed |
| pubmed-article:2159827 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2159827 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:2159827 | pubmed:volume | 512 | lld:pubmed |
| pubmed-article:2159827 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2159827 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2159827 | pubmed:pagination | 26-32 | lld:pubmed |
| pubmed-article:2159827 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2159827 | pubmed:meshHeading | pubmed-meshheading:2159827-... | lld:pubmed |
| pubmed-article:2159827 | pubmed:meshHeading | pubmed-meshheading:2159827-... | lld:pubmed |
| pubmed-article:2159827 | pubmed:meshHeading | pubmed-meshheading:2159827-... | lld:pubmed |
| pubmed-article:2159827 | pubmed:meshHeading | pubmed-meshheading:2159827-... | lld:pubmed |
| pubmed-article:2159827 | pubmed:meshHeading | pubmed-meshheading:2159827-... | lld:pubmed |
| pubmed-article:2159827 | pubmed:meshHeading | pubmed-meshheading:2159827-... | lld:pubmed |
| pubmed-article:2159827 | pubmed:meshHeading | pubmed-meshheading:2159827-... | lld:pubmed |
| pubmed-article:2159827 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2159827 | pubmed:articleTitle | Pyrethroid modifications of the activation and inactivation kinetics of the sodium channels in squid giant axons. | lld:pubmed |
| pubmed-article:2159827 | pubmed:affiliation | Department of Pharmacology, Northwestern University Medical School, Chicago, IL 60611. | lld:pubmed |
| pubmed-article:2159827 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2159827 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2159827 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
