| pubmed-article:21595441 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21595441 | lifeskim:mentions | umls-concept:C0023767 | lld:lifeskim |
| pubmed-article:21595441 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:21595441 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:21595441 | lifeskim:mentions | umls-concept:C0336791 | lld:lifeskim |
| pubmed-article:21595441 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:21595441 | pubmed:dateCreated | 2011-6-30 | lld:pubmed |
| pubmed-article:21595441 | pubmed:abstractText | The utility of 193-nm ultraviolet photodissociation (UVPD) and 10.6-?m infrared multiphoton dissociation (IRMPD) for the characterization of lipid A structures was assessed in an ion trap mass spectrometer. The fragmentation behavior of lipid A species was also evaluated by activated-electron photodetachment (a-EPD), which uses 193-nm photons to create charge reduced radicals that are subsequently dissociated by collisional activation. In contrast to collision-induced dissociation (CID), IRMPD offered the ability to selectively differentiate product ions with varying degrees of phosphorylation because of the increased photoabsorption cross sections and thus dissociation of phosphate-containing species. Both 193-nm UVPD and a-EPD yielded higher abundances and a larger array of product ions arising from C-C cleavages, as well as cross-ring and inter-ring glucosamine cleavages, compared to CID and IRMPD, because of high energy, single-photon absorption, and/or radical-directed dissociation. UVPD at 193 nm also exhibited enhanced cleavage between the amine and carbonyl groups on the 2- and 2'-linked primary acyl chains. Lastly, UVPD of phosphorylethanolamine-modified lipid A species resulted in preferential cleavage of the C-O bond between ethanolamine and phosphate, enabling the selective identification of this modification. | lld:pubmed |
| pubmed-article:21595441 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21595441 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21595441 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21595441 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21595441 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21595441 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21595441 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21595441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21595441 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21595441 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:21595441 | pubmed:issn | 1520-6882 | lld:pubmed |
| pubmed-article:21595441 | pubmed:author | pubmed-author:BrodbeltJenni... | lld:pubmed |
| pubmed-article:21595441 | pubmed:author | pubmed-author:TrentM... | lld:pubmed |
| pubmed-article:21595441 | pubmed:author | pubmed-author:CullenThomas... | lld:pubmed |
| pubmed-article:21595441 | pubmed:author | pubmed-author:MadsenJames... | lld:pubmed |
| pubmed-article:21595441 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21595441 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:21595441 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:21595441 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21595441 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21595441 | pubmed:pagination | 5107-13 | lld:pubmed |
| pubmed-article:21595441 | pubmed:meshHeading | pubmed-meshheading:21595441... | lld:pubmed |
| pubmed-article:21595441 | pubmed:meshHeading | pubmed-meshheading:21595441... | lld:pubmed |
| pubmed-article:21595441 | pubmed:meshHeading | pubmed-meshheading:21595441... | lld:pubmed |
| pubmed-article:21595441 | pubmed:meshHeading | pubmed-meshheading:21595441... | lld:pubmed |
| pubmed-article:21595441 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21595441 | pubmed:articleTitle | IR and UV photodissociation as analytical tools for characterizing lipid A structures. | lld:pubmed |
| pubmed-article:21595441 | pubmed:affiliation | Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA. | lld:pubmed |
| pubmed-article:21595441 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21595441 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:21595441 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21595441 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
