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pubmed-article:21576633pubmed:abstractTextBlinatumomab, a bispecific single-chain antibody targeting the CD19 antigen, is a member of a novel class of antibodies that redirect T cells for selective lysis of tumor cells. In acute lymphoblastic leukemia (ALL), persistence or relapse of minimal residual disease (MRD) after chemotherapy indicates resistance to chemotherapy and results in hematologic relapse. A phase II clinical study was conducted to determine the efficacy of blinatumomab in MRD-positive B-lineage ALL.lld:pubmed
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pubmed-article:21576633pubmed:articleTitleTargeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival.lld:pubmed
pubmed-article:21576633pubmed:affiliationComprehensive Cancer Center Mainfranken, University Wuerzburg, Germany.lld:pubmed
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