| pubmed-article:21566115 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21566115 | lifeskim:mentions | umls-concept:C1367307 | lld:lifeskim |
| pubmed-article:21566115 | lifeskim:mentions | umls-concept:C1417706 | lld:lifeskim |
| pubmed-article:21566115 | lifeskim:mentions | umls-concept:C0205108 | lld:lifeskim |
| pubmed-article:21566115 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:21566115 | lifeskim:mentions | umls-concept:C1334102 | lld:lifeskim |
| pubmed-article:21566115 | lifeskim:mentions | umls-concept:C0920533 | lld:lifeskim |
| pubmed-article:21566115 | lifeskim:mentions | umls-concept:C1515557 | lld:lifeskim |
| pubmed-article:21566115 | lifeskim:mentions | umls-concept:C0086222 | lld:lifeskim |
| pubmed-article:21566115 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:21566115 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:21566115 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:21566115 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:21566115 | lifeskim:mentions | umls-concept:C1705733 | lld:lifeskim |
| pubmed-article:21566115 | pubmed:issue | 26 | lld:pubmed |
| pubmed-article:21566115 | pubmed:dateCreated | 2011-6-27 | lld:pubmed |
| pubmed-article:21566115 | pubmed:abstractText | Deregulated IL-12 and IL-23 production from activated myeloid lineage cells is a key driver of numerous T cell-dependent autoimmune and inflammatory diseases. IL-12 and IL-23 share a common p40 subunit encoded by Il12b, which is negatively regulated at the transcriptional level by the STAT3 (signal transducer and activator of transcription 3)-activating anti-inflammatory cytokine IL-10. We found that IL-10 targets an enhancer 10 kb upstream of the Il12b transcriptional start site. Within the enhancer, a single 10-bp site is required for the inhibitory effects of IL-10 and is bound by NFIL3 (nuclear factor, interleukin 3-regulated), a B-ZIP transcription factor. Myeloid cells lacking NFIL3 produce excessive IL-12p40 and increased IL-12p70. Thus, the STAT3-dependent expression of NFIL3 is a key component of a negative feedback pathway in myeloid cells that suppresses proinflammatory responses. | lld:pubmed |
| pubmed-article:21566115 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21566115 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21566115 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21566115 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21566115 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21566115 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21566115 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21566115 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21566115 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:21566115 | pubmed:issn | 1083-351X | lld:pubmed |
| pubmed-article:21566115 | pubmed:author | pubmed-author:JohnsonPeter... | lld:pubmed |
| pubmed-article:21566115 | pubmed:author | pubmed-author:MurrayPeter... | lld:pubmed |
| pubmed-article:21566115 | pubmed:author | pubmed-author:SmaleStephen... | lld:pubmed |
| pubmed-article:21566115 | pubmed:author | pubmed-author:O'BrienKevinK | lld:pubmed |
| pubmed-article:21566115 | pubmed:author | pubmed-author:Schultz-Cherr... | lld:pubmed |
| pubmed-article:21566115 | pubmed:author | pubmed-author:QuallsJoseph... | lld:pubmed |
| pubmed-article:21566115 | pubmed:author | pubmed-author:SmithAmber... | lld:pubmed |
| pubmed-article:21566115 | pubmed:author | pubmed-author:BalouzianLiza... | lld:pubmed |
| pubmed-article:21566115 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21566115 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:21566115 | pubmed:volume | 286 | lld:pubmed |
| pubmed-article:21566115 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21566115 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21566115 | pubmed:pagination | 23582-90 | lld:pubmed |
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| pubmed-article:21566115 | pubmed:meshHeading | pubmed-meshheading:21566115... | lld:pubmed |
| pubmed-article:21566115 | pubmed:meshHeading | pubmed-meshheading:21566115... | lld:pubmed |
| pubmed-article:21566115 | pubmed:meshHeading | pubmed-meshheading:21566115... | lld:pubmed |
| pubmed-article:21566115 | pubmed:meshHeading | pubmed-meshheading:21566115... | lld:pubmed |
| pubmed-article:21566115 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21566115 | pubmed:articleTitle | A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3. | lld:pubmed |
| pubmed-article:21566115 | pubmed:affiliation | Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. | lld:pubmed |
| pubmed-article:21566115 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21566115 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21566115 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| pubmed-article:21566115 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
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