| pubmed-article:2156154 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2156154 | lifeskim:mentions | umls-concept:C0206558 | lld:lifeskim |
| pubmed-article:2156154 | lifeskim:mentions | umls-concept:C0003451 | lld:lifeskim |
| pubmed-article:2156154 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2156154 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:2156154 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:2156154 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:2156154 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2156154 | lifeskim:mentions | umls-concept:C0243126 | lld:lifeskim |
| pubmed-article:2156154 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:2156154 | lifeskim:mentions | umls-concept:C0048983 | lld:lifeskim |
| pubmed-article:2156154 | lifeskim:mentions | umls-concept:C0205198 | lld:lifeskim |
| pubmed-article:2156154 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2156154 | pubmed:dateCreated | 1990-4-26 | lld:pubmed |
| pubmed-article:2156154 | pubmed:abstractText | The carbocyclic analogue of (E)-5-(2-iodovinyl)-2'-deoxyuridine (C-IVDU) is, like its parent compound (E)-5-(2-iodovinyl)-2'-deoxyuridine (IVDU), a potent and selective inhibitor of herpes simplex virus type 1 (HSV-1). There is a close correlation between the inhibition of viral DNA synthesis and the antiviral activity of both IVDU and C-IVDU. IVDU and C-IVDU inhibit viral DNA synthesis at 0.2 and 0.5 microM, respectively, and interfere with cellular DNA synthesis at concentrations that are 10- to 40-fold in excess of their antivirally effective doses. At concentrations affording a similar antiviral effect, C-[125I]IVDU is incorporated into viral and cellular DNA of HSV-1-infected Vero cells to a 7- to 10-fold lesser extent than IVDU. [125I]IVDU but not C-[125I]IVDU leads to breakage of both DNA strands when incorporated into HSV-1 DNA. | lld:pubmed |
| pubmed-article:2156154 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2156154 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2156154 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2156154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2156154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2156154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2156154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2156154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2156154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2156154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2156154 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2156154 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2156154 | pubmed:issn | 0026-895X | lld:pubmed |
| pubmed-article:2156154 | pubmed:author | pubmed-author:De ClercqEE | lld:pubmed |
| pubmed-article:2156154 | pubmed:author | pubmed-author:VerbruggenAA | lld:pubmed |
| pubmed-article:2156154 | pubmed:author | pubmed-author:BalzariniJJ | lld:pubmed |
| pubmed-article:2156154 | pubmed:author | pubmed-author:BernaertsRR | lld:pubmed |
| pubmed-article:2156154 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2156154 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:2156154 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2156154 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2156154 | pubmed:pagination | 402-7 | lld:pubmed |
| pubmed-article:2156154 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2156154 | pubmed:meshHeading | pubmed-meshheading:2156154-... | lld:pubmed |
| pubmed-article:2156154 | pubmed:meshHeading | pubmed-meshheading:2156154-... | lld:pubmed |
| pubmed-article:2156154 | pubmed:meshHeading | pubmed-meshheading:2156154-... | lld:pubmed |
| pubmed-article:2156154 | pubmed:meshHeading | pubmed-meshheading:2156154-... | lld:pubmed |
| pubmed-article:2156154 | pubmed:meshHeading | pubmed-meshheading:2156154-... | lld:pubmed |
| pubmed-article:2156154 | pubmed:meshHeading | pubmed-meshheading:2156154-... | lld:pubmed |
| pubmed-article:2156154 | pubmed:meshHeading | pubmed-meshheading:2156154-... | lld:pubmed |
| pubmed-article:2156154 | pubmed:meshHeading | pubmed-meshheading:2156154-... | lld:pubmed |
| pubmed-article:2156154 | pubmed:meshHeading | pubmed-meshheading:2156154-... | lld:pubmed |
| pubmed-article:2156154 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2156154 | pubmed:articleTitle | Role of the incorporation of (E)-5-(2-iodovinyl)-2'-deoxyuridine and its carbocyclic analogue into DNA of herpes simplex virus type 1-infected cells in the antiviral effects of these compounds. | lld:pubmed |
| pubmed-article:2156154 | pubmed:affiliation | Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium. | lld:pubmed |
| pubmed-article:2156154 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2156154 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2156154 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2156154 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2156154 | lld:pubmed |
