| pubmed-article:21557958 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21557958 | lifeskim:mentions | umls-concept:C0085281 | lld:lifeskim |
| pubmed-article:21557958 | lifeskim:mentions | umls-concept:C0016452 | lld:lifeskim |
| pubmed-article:21557958 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:21557958 | pubmed:dateCreated | 2011-6-3 | lld:pubmed |
| pubmed-article:21557958 | pubmed:abstractText | In drug addiction, the transition from casual drug use to dependence has been linked to a shift away from positive reinforcement and toward negative reinforcement. That is, drugs ultimately are relied on to prevent or relieve negative states that otherwise result from abstinence (e.g., withdrawal) or from adverse environmental circumstances (e.g., stress). Recent work has suggested that this "dark side" shift also is a key in the development of food addiction. Initially, palatable food consumption has both positively reinforcing, pleasurable effects and negatively reinforcing, "comforting" effects that can acutely normalize organism responses to stress. Repeated, intermittent intake of palatable food may instead amplify brain stress circuitry and downregulate brain reward pathways such that continued intake becomes obligatory to prevent negative emotional states via negative reinforcement. Stress, anxiety and depressed mood have shown high comorbidity with and the potential to trigger bouts of addiction-like eating behavior in humans. Animal models indicate that repeated, intermittent access to palatable foods can lead to emotional and somatic signs of withdrawal when the food is no longer available, tolerance and dampening of brain reward circuitry, compulsive seeking of palatable food despite potentially aversive consequences, and relapse to palatable food-seeking in response to anxiogenic-like stimuli. The neurocircuitry identified to date in the "dark" side of food addiction qualitatively resembles that associated with drug and alcohol dependence. The present review summarizes Bart Hoebel's groundbreaking conceptual and empirical contributions to understanding the role of the "dark side" in food addiction along with related work of those that have followed him. | lld:pubmed |
| pubmed-article:21557958 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21557958 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21557958 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21557958 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21557958 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21557958 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21557958 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21557958 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21557958 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21557958 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21557958 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21557958 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21557958 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21557958 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21557958 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21557958 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:21557958 | pubmed:issn | 1873-507X | lld:pubmed |
| pubmed-article:21557958 | pubmed:author | pubmed-author:KoobGeorge... | lld:pubmed |
| pubmed-article:21557958 | pubmed:author | pubmed-author:ZorrillaEric... | lld:pubmed |
| pubmed-article:21557958 | pubmed:author | pubmed-author:ParylakSarah... | lld:pubmed |
| pubmed-article:21557958 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:21557958 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21557958 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:21557958 | pubmed:volume | 104 | lld:pubmed |
| pubmed-article:21557958 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21557958 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21557958 | pubmed:pagination | 149-56 | lld:pubmed |
| pubmed-article:21557958 | pubmed:meshHeading | pubmed-meshheading:21557958... | lld:pubmed |
| pubmed-article:21557958 | pubmed:meshHeading | pubmed-meshheading:21557958... | lld:pubmed |
| pubmed-article:21557958 | pubmed:meshHeading | pubmed-meshheading:21557958... | lld:pubmed |
| pubmed-article:21557958 | pubmed:meshHeading | pubmed-meshheading:21557958... | lld:pubmed |
| pubmed-article:21557958 | pubmed:meshHeading | pubmed-meshheading:21557958... | lld:pubmed |
| pubmed-article:21557958 | pubmed:meshHeading | pubmed-meshheading:21557958... | lld:pubmed |
| pubmed-article:21557958 | pubmed:meshHeading | pubmed-meshheading:21557958... | lld:pubmed |
| pubmed-article:21557958 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21557958 | pubmed:articleTitle | The dark side of food addiction. | lld:pubmed |
| pubmed-article:21557958 | pubmed:affiliation | Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA. sparylak@ucsd.edu | lld:pubmed |
| pubmed-article:21557958 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21557958 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:21557958 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21557958 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
