| pubmed-article:21555853 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21555853 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:21555853 | lifeskim:mentions | umls-concept:C0025933 | lld:lifeskim |
| pubmed-article:21555853 | lifeskim:mentions | umls-concept:C0020507 | lld:lifeskim |
| pubmed-article:21555853 | lifeskim:mentions | umls-concept:C0034839 | lld:lifeskim |
| pubmed-article:21555853 | lifeskim:mentions | umls-concept:C1256369 | lld:lifeskim |
| pubmed-article:21555853 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:21555853 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:21555853 | pubmed:dateCreated | 2011-6-2 | lld:pubmed |
| pubmed-article:21555853 | pubmed:abstractText | Insulin, growth hormone (GH), and insulin-like growth factor-1 (IGF-1) play key roles in the regulation of ? cell growth and function. Although ? cells express the GH receptor, the direct effects of GH on ? cells remain largely unknown. Here we have employed a rat insulin II promoter-driven (RIP-driven) Cre recombinase to disrupt the GH receptor in ? cells (?GHRKO). ?GHRKO mice fed a standard chow diet exhibited impaired glucose-stimulated insulin secretion but had no changes in ? cell mass. When challenged with a high-fat diet, ?GHRKO mice showed evidence of a ? cell secretory defect, with further deterioration of glucose homeostasis indicated by their altered glucose tolerance and blunted glucose-stimulated insulin secretion. Interestingly, ?GHRKO mice were impaired in ? cell hyperplasia in response to a high-fat diet, with decreased ? cell proliferation and overall reduced ? cell mass. Therefore, GH receptor plays critical roles in glucose-stimulated insulin secretion and ? cell compensation in response to a high-fat diet. | lld:pubmed |
| pubmed-article:21555853 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21555853 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:21555853 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555853 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21555853 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:21555853 | pubmed:issn | 1558-8238 | lld:pubmed |
| pubmed-article:21555853 | pubmed:author | pubmed-author:SunHuiH | lld:pubmed |
| pubmed-article:21555853 | pubmed:author | pubmed-author:YakarShoshana... | lld:pubmed |
| pubmed-article:21555853 | pubmed:author | pubmed-author:LeRoithDerekD | lld:pubmed |
| pubmed-article:21555853 | pubmed:author | pubmed-author:LiuChengyuC | lld:pubmed |
| pubmed-article:21555853 | pubmed:author | pubmed-author:WuYingjieY | lld:pubmed |
| pubmed-article:21555853 | pubmed:author | pubmed-author:QiaoRuifangR | lld:pubmed |
| pubmed-article:21555853 | pubmed:author | pubmed-author:GiglouPejman... | lld:pubmed |
| pubmed-article:21555853 | pubmed:author | pubmed-author:VijayakumarAr... | lld:pubmed |
| pubmed-article:21555853 | pubmed:author | pubmed-author:OppenheimerJo... | lld:pubmed |
| pubmed-article:21555853 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21555853 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:21555853 | pubmed:volume | 121 | lld:pubmed |
| pubmed-article:21555853 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21555853 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21555853 | pubmed:pagination | 2422-6 | lld:pubmed |
| pubmed-article:21555853 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:21555853 | pubmed:meshHeading | pubmed-meshheading:21555853... | lld:pubmed |
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| pubmed-article:21555853 | pubmed:meshHeading | pubmed-meshheading:21555853... | lld:pubmed |
| pubmed-article:21555853 | pubmed:meshHeading | pubmed-meshheading:21555853... | lld:pubmed |
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| pubmed-article:21555853 | pubmed:meshHeading | pubmed-meshheading:21555853... | lld:pubmed |
| pubmed-article:21555853 | pubmed:meshHeading | pubmed-meshheading:21555853... | lld:pubmed |
| pubmed-article:21555853 | pubmed:meshHeading | pubmed-meshheading:21555853... | lld:pubmed |
| pubmed-article:21555853 | pubmed:meshHeading | pubmed-meshheading:21555853... | lld:pubmed |
| pubmed-article:21555853 | pubmed:meshHeading | pubmed-meshheading:21555853... | lld:pubmed |
| pubmed-article:21555853 | pubmed:meshHeading | pubmed-meshheading:21555853... | lld:pubmed |
| pubmed-article:21555853 | pubmed:meshHeading | pubmed-meshheading:21555853... | lld:pubmed |
| pubmed-article:21555853 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21555853 | pubmed:articleTitle | Growth hormone receptor regulates ? cell hyperplasia and glucose-stimulated insulin secretion in obese mice. | lld:pubmed |
| pubmed-article:21555853 | pubmed:affiliation | Division of Endocrinology, Diabetes and Bone Disease, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA. | lld:pubmed |
| pubmed-article:21555853 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:14600 | entrezgene:pubmed | pubmed-article:21555853 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21555853 | lld:entrezgene |
