| pubmed-article:21555851 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21555851 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:21555851 | lifeskim:mentions | umls-concept:C0025202 | lld:lifeskim |
| pubmed-article:21555851 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:21555851 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:21555851 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:21555851 | lifeskim:mentions | umls-concept:C0027627 | lld:lifeskim |
| pubmed-article:21555851 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:21555851 | lifeskim:mentions | umls-concept:C0392674 | lld:lifeskim |
| pubmed-article:21555851 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:21555851 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:21555851 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:21555851 | pubmed:dateCreated | 2011-6-2 | lld:pubmed |
| pubmed-article:21555851 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:abstractText | In chronic viral infections, CD8? T cells become functionally deficient and display multiple molecular alterations. In contrast, only little is known of self- and tumor-specific CD8? T cells from mice and humans. Here we determined molecular profiles of tumor-specific CD8? T cells from melanoma patients. In peripheral blood from patients vaccinated with CpG and the melanoma antigen Melan-A/MART-1 peptide, we found functional effector T cell populations, with only small but nevertheless significant differences in T cells specific for persistent herpesviruses (EBV and CMV). In contrast, Melan-A/MART-1-specific T cells isolated from metastases from patients with melanoma expressed a large variety of genes associated with T cell exhaustion. The identified exhaustion profile revealed extended molecular alterations. Our data demonstrate a remarkable coexistence of effector cells in circulation and exhausted cells in the tumor environment. Functional T cell impairment is mediated by inhibitory receptors and further molecular pathways, which represent potential targets for cancer therapy. | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21555851 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:21555851 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555851 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21555851 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:21555851 | pubmed:issn | 1558-8238 | lld:pubmed |
| pubmed-article:21555851 | pubmed:author | pubmed-author:DeplanckeBart... | lld:pubmed |
| pubmed-article:21555851 | pubmed:author | pubmed-author:RomeroPedroP | lld:pubmed |
| pubmed-article:21555851 | pubmed:author | pubmed-author:SpeiserDaniel... | lld:pubmed |
| pubmed-article:21555851 | pubmed:author | pubmed-author:RuferNathalie... | lld:pubmed |
| pubmed-article:21555851 | pubmed:author | pubmed-author:BouzoureneHan... | lld:pubmed |
| pubmed-article:21555851 | pubmed:author | pubmed-author:BaumgaertnerP... | lld:pubmed |
| pubmed-article:21555851 | pubmed:author | pubmed-author:WieckowskiSéb... | lld:pubmed |
| pubmed-article:21555851 | pubmed:author | pubmed-author:RaghavSunil... | lld:pubmed |
| pubmed-article:21555851 | pubmed:author | pubmed-author:DevêvreEstell... | lld:pubmed |
| pubmed-article:21555851 | pubmed:author | pubmed-author:LegatAmandine... | lld:pubmed |
| pubmed-article:21555851 | pubmed:author | pubmed-author:BaitschLukasL | lld:pubmed |
| pubmed-article:21555851 | pubmed:author | pubmed-author:BarbaLeticiaL | lld:pubmed |
| pubmed-article:21555851 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21555851 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:21555851 | pubmed:volume | 121 | lld:pubmed |
| pubmed-article:21555851 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21555851 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21555851 | pubmed:pagination | 2350-60 | lld:pubmed |
| pubmed-article:21555851 | pubmed:meshHeading | pubmed-meshheading:21555851... | lld:pubmed |
| pubmed-article:21555851 | pubmed:meshHeading | pubmed-meshheading:21555851... | lld:pubmed |
| pubmed-article:21555851 | pubmed:meshHeading | pubmed-meshheading:21555851... | lld:pubmed |
| pubmed-article:21555851 | pubmed:meshHeading | pubmed-meshheading:21555851... | lld:pubmed |
| pubmed-article:21555851 | pubmed:meshHeading | pubmed-meshheading:21555851... | lld:pubmed |
| pubmed-article:21555851 | pubmed:meshHeading | pubmed-meshheading:21555851... | lld:pubmed |
| pubmed-article:21555851 | pubmed:meshHeading | pubmed-meshheading:21555851... | lld:pubmed |
| pubmed-article:21555851 | pubmed:meshHeading | pubmed-meshheading:21555851... | lld:pubmed |
