| pubmed-article:21555452 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21555452 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:21555452 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:21555452 | lifeskim:mentions | umls-concept:C1539599 | lld:lifeskim |
| pubmed-article:21555452 | lifeskim:mentions | umls-concept:C0015744 | lld:lifeskim |
| pubmed-article:21555452 | lifeskim:mentions | umls-concept:C2911691 | lld:lifeskim |
| pubmed-article:21555452 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:21555452 | lifeskim:mentions | umls-concept:C0205360 | lld:lifeskim |
| pubmed-article:21555452 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:21555452 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:21555452 | pubmed:dateCreated | 2011-6-10 | lld:pubmed |
| pubmed-article:21555452 | pubmed:abstractText | Oxygen-dependent regulation of the transcription factor HIF-1? relies on a family of prolyl hydroxylases (PHDs) that hydroxylate hypoxia-inducible factor 1? (HIF-1?) protein at two prolines during normal oxygen conditions, resulting in degradation by the proteasome. During low-oxygen conditions, these prolines are no longer hydroxylated and HIF-1? degradation is blocked. Hypoxia-induced miRNA-210 (miR-210) is a direct transcriptional target of HIF-1?, but its complete role and targets during hypoxia are not well understood. Here, we identify the enzyme glycerol-3-phosphate dehydrogenase 1-like (GPD1L) as a novel regulator of HIF-1? stability and a direct target of miR-210. Expression of miR-210 results in stabilization of HIF-1? due to decreased levels of GPD1L resulting in an increase in HIF-1? target genes. Altering GPD1L levels by overexpression or knockdown results in a decrease or increase in HIF-1? stability, respectively. GPD1L-mediated decreases in HIF-1? stability can be reversed by pharmacological inhibition of the proteasome or PHD activity. When rescued from degradation by proteasome inhibition, elevated amounts of GPD1L cause hyperhydroxylation of HIF-1?, suggesting increases in PHD activity. Importantly, expression of GPD1L attenuates the hypoxic response, preventing complete HIF-1? induction. We propose a model in which hypoxia-induced miR-210 represses GPD1L, contributing to suppression of PHD activity, and increases of HIF-1? protein levels. | lld:pubmed |
| pubmed-article:21555452 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555452 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21555452 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555452 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21555452 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555452 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555452 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555452 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555452 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555452 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21555452 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:21555452 | pubmed:issn | 1098-5549 | lld:pubmed |
| pubmed-article:21555452 | pubmed:author | pubmed-author:PuigserverPer... | lld:pubmed |
| pubmed-article:21555452 | pubmed:author | pubmed-author:ClishClary... | lld:pubmed |
| pubmed-article:21555452 | pubmed:author | pubmed-author:KellyTimothy... | lld:pubmed |
| pubmed-article:21555452 | pubmed:author | pubmed-author:SouzaAmanda... | lld:pubmed |
| pubmed-article:21555452 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21555452 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:21555452 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21555452 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21555452 | pubmed:pagination | 2696-706 | lld:pubmed |
| pubmed-article:21555452 | pubmed:meshHeading | pubmed-meshheading:21555452... | lld:pubmed |
| pubmed-article:21555452 | pubmed:meshHeading | pubmed-meshheading:21555452... | lld:pubmed |
| pubmed-article:21555452 | pubmed:meshHeading | pubmed-meshheading:21555452... | lld:pubmed |
| pubmed-article:21555452 | pubmed:meshHeading | pubmed-meshheading:21555452... | lld:pubmed |
| pubmed-article:21555452 | pubmed:meshHeading | pubmed-meshheading:21555452... | lld:pubmed |
| pubmed-article:21555452 | pubmed:meshHeading | pubmed-meshheading:21555452... | lld:pubmed |
| pubmed-article:21555452 | pubmed:meshHeading | pubmed-meshheading:21555452... | lld:pubmed |
| pubmed-article:21555452 | pubmed:meshHeading | pubmed-meshheading:21555452... | lld:pubmed |
| pubmed-article:21555452 | pubmed:meshHeading | pubmed-meshheading:21555452... | lld:pubmed |
| pubmed-article:21555452 | pubmed:meshHeading | pubmed-meshheading:21555452... | lld:pubmed |
| pubmed-article:21555452 | pubmed:meshHeading | pubmed-meshheading:21555452... | lld:pubmed |
| pubmed-article:21555452 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21555452 | pubmed:articleTitle | A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like. | lld:pubmed |
| pubmed-article:21555452 | pubmed:affiliation | Department of Cancer Biology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:21555452 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21555452 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:21555452 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21555452 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:3091 | entrezgene:pubmed | pubmed-article:21555452 | lld:entrezgene |
| entrez-gene:23171 | entrezgene:pubmed | pubmed-article:21555452 | lld:entrezgene |
| entrez-gene:406992 | entrezgene:pubmed | pubmed-article:21555452 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21555452 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21555452 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21555452 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:21555452 | lld:pubmed |
