| pubmed-article:21555073 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21555073 | lifeskim:mentions | umls-concept:C0003577 | lld:lifeskim |
| pubmed-article:21555073 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:21555073 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:21555073 | lifeskim:mentions | umls-concept:C0234112 | lld:lifeskim |
| pubmed-article:21555073 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:21555073 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:21555073 | pubmed:dateCreated | 2011-5-10 | lld:pubmed |
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| pubmed-article:21555073 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555073 | pubmed:abstractText | Neurexin and neuroligin, which undergo heterophilic interactions with each other at the synapse, are mutated in some patients with autism spectrum disorder, a set of disorders characterized by deficits in social and emotional learning. We have explored the role of neurexin and neuroligin at sensory-to-motor neuron synapses of the gill-withdrawal reflex in Aplysia, which undergoes sensitization, a simple form of learned fear. We find that depleting neurexin in the presynaptic sensory neuron or neuroligin in the postsynaptic motor neuron abolishes both long-term facilitation and the associated presynaptic growth induced by repeated pulses of serotonin. Moreover, introduction into the motor neuron of the R451C mutation of neuroligin-3 linked to autism spectrum disorder blocks both intermediate-term and long-term facilitation. Our results suggest that activity-dependent regulation of the neurexin-neuroligin interaction may govern transsynaptic signaling required for the storage of long-term memory, including emotional memory that may be impaired in autism spectrum disorder. | lld:pubmed |
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| pubmed-article:21555073 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21555073 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555073 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21555073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21555073 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21555073 | pubmed:month | May | lld:pubmed |
| pubmed-article:21555073 | pubmed:issn | 1097-4199 | lld:pubmed |
| pubmed-article:21555073 | pubmed:author | pubmed-author:KandelEric... | lld:pubmed |
| pubmed-article:21555073 | pubmed:author | pubmed-author:ZANARR | lld:pubmed |
| pubmed-article:21555073 | pubmed:author | pubmed-author:KimJoung-HunJ... | lld:pubmed |
| pubmed-article:21555073 | pubmed:author | pubmed-author:ChoiYun-BeomY... | lld:pubmed |
| pubmed-article:21555073 | pubmed:author | pubmed-author:KassabovStefa... | lld:pubmed |
| pubmed-article:21555073 | pubmed:author | pubmed-author:JinIksungI | lld:pubmed |
| pubmed-article:21555073 | pubmed:author | pubmed-author:LiHsiu-LingHL | lld:pubmed |
| pubmed-article:21555073 | pubmed:author | pubmed-author:BaileyCraig... | lld:pubmed |
| pubmed-article:21555073 | pubmed:author | pubmed-author:Puthanveettil... | lld:pubmed |
| pubmed-article:21555073 | pubmed:author | pubmed-author:KarlKevin AKA | lld:pubmed |
| pubmed-article:21555073 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:21555073 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21555073 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:21555073 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:21555073 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21555073 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21555073 | pubmed:pagination | 468-81 | lld:pubmed |
| pubmed-article:21555073 | pubmed:dateRevised | 2011-11-14 | lld:pubmed |
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| pubmed-article:21555073 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21555073 | pubmed:articleTitle | Neurexin-neuroligin transsynaptic interaction mediates learning-related synaptic remodeling and long-term facilitation in aplysia. | lld:pubmed |
| pubmed-article:21555073 | pubmed:affiliation | Department of Neurology, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA. | lld:pubmed |
| pubmed-article:21555073 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21555073 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21555073 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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