| pubmed-article:21536891 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21536891 | lifeskim:mentions | umls-concept:C0680022 | lld:lifeskim |
| pubmed-article:21536891 | lifeskim:mentions | umls-concept:C0600518 | lld:lifeskim |
| pubmed-article:21536891 | lifeskim:mentions | umls-concept:C1704332 | lld:lifeskim |
| pubmed-article:21536891 | lifeskim:mentions | umls-concept:C1160251 | lld:lifeskim |
| pubmed-article:21536891 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:21536891 | pubmed:dateCreated | 2011-5-18 | lld:pubmed |
| pubmed-article:21536891 | pubmed:abstractText | MicroRNAs (miRNAs) modulate complex physiological and pathological processes by repressing expression of multiple components of cellular regulatory networks. Here we demonstrate that miRNAs encoded by the miR-23?27?24 gene clusters are enriched in endothelial cells and highly vascularized tissues. Inhibition of miR-23 and miR-27 function by locked nucleic acid-modified anti-miRNAs represses angiogenesis in vitro and postnatal retinal vascular development in vivo. Moreover, miR-23 and miR-27 are required for pathological angiogenesis in a laser-induced choroidal neovascularization mouse model. MiR-23 and miR-27 enhance angiogenesis by promoting angiogenic signaling through targeting Sprouty2 and Sema6A proteins, which exert antiangiogenic activity. Manipulating miR-23/27 levels may have important therapeutic implications in neovascular age-related macular degeneration and other vascular disorders. | lld:pubmed |
| pubmed-article:21536891 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21536891 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21536891 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21536891 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21536891 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21536891 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21536891 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21536891 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21536891 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21536891 | pubmed:month | May | lld:pubmed |
| pubmed-article:21536891 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:21536891 | pubmed:author | pubmed-author:OlsonEric NEN | lld:pubmed |
| pubmed-article:21536891 | pubmed:author | pubmed-author:WangShushengS | lld:pubmed |
| pubmed-article:21536891 | pubmed:author | pubmed-author:LiXinyuX | lld:pubmed |
| pubmed-article:21536891 | pubmed:author | pubmed-author:GallagherRach... | lld:pubmed |
| pubmed-article:21536891 | pubmed:author | pubmed-author:ZhouQinboQ | lld:pubmed |
| pubmed-article:21536891 | pubmed:author | pubmed-author:Ufret-Vincent... | lld:pubmed |
| pubmed-article:21536891 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21536891 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:21536891 | pubmed:volume | 108 | lld:pubmed |
| pubmed-article:21536891 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21536891 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21536891 | pubmed:pagination | 8287-92 | lld:pubmed |
| pubmed-article:21536891 | pubmed:meshHeading | pubmed-meshheading:21536891... | lld:pubmed |
| pubmed-article:21536891 | pubmed:meshHeading | pubmed-meshheading:21536891... | lld:pubmed |
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| pubmed-article:21536891 | pubmed:meshHeading | pubmed-meshheading:21536891... | lld:pubmed |
| pubmed-article:21536891 | pubmed:meshHeading | pubmed-meshheading:21536891... | lld:pubmed |
| pubmed-article:21536891 | pubmed:meshHeading | pubmed-meshheading:21536891... | lld:pubmed |
| pubmed-article:21536891 | pubmed:meshHeading | pubmed-meshheading:21536891... | lld:pubmed |
| pubmed-article:21536891 | pubmed:meshHeading | pubmed-meshheading:21536891... | lld:pubmed |
| pubmed-article:21536891 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21536891 | pubmed:articleTitle | Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters. | lld:pubmed |
| pubmed-article:21536891 | pubmed:affiliation | Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. | lld:pubmed |
| pubmed-article:21536891 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21536891 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21536891 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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