| pubmed-article:2153410 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2153410 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:2153410 | lifeskim:mentions | umls-concept:C0001455 | lld:lifeskim |
| pubmed-article:2153410 | lifeskim:mentions | umls-concept:C0008387 | lld:lifeskim |
| pubmed-article:2153410 | lifeskim:mentions | umls-concept:C0014894 | lld:lifeskim |
| pubmed-article:2153410 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:2153410 | lifeskim:mentions | umls-concept:C2825492 | lld:lifeskim |
| pubmed-article:2153410 | lifeskim:mentions | umls-concept:C1882074 | lld:lifeskim |
| pubmed-article:2153410 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2153410 | pubmed:dateCreated | 1990-2-27 | lld:pubmed |
| pubmed-article:2153410 | pubmed:abstractText | Cholesteryl ester laden foam cells in atherosclerotic lesions derive, in part, from macrophages. Mobilization of stored cholesteryl esters involves hydrolysis by a neutral cholesteryl ester hydrolase. Incubation of intact P388D1 macrophages with dibutyryl cAMP in the presence of 1-methyl-3-isobutylxanthine resulted in a dose-dependent increase in neutral cholesteryl ester hydrolase activity of up to 50% (ED50 = 0.1 mM). Incubation with prostaglandin E1 in the presence of 1-methyl-3-isobutylxanthine also increased neutral cholesterol ester hydrolase activity by about 50%. In cell-free preparation, cAMP-dependent protein kinase caused about a 2-fold activation of the neutral cholesteryl ester hydrolase. Activation was blocked by protein kinase inhibitor. These data suggest that the P388D1 macrophage may be a useful model for studying the hormonal regulation of cholesteryl ester mobilization in macrophage-derived foam cells. | lld:pubmed |
| pubmed-article:2153410 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2153410 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2153410 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2153410 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2153410 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2153410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2153410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2153410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2153410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2153410 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2153410 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2153410 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:2153410 | pubmed:author | pubmed-author:MAUSW KWK | lld:pubmed |
| pubmed-article:2153410 | pubmed:author | pubmed-author:GoldbergD IDI | lld:pubmed |
| pubmed-article:2153410 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2153410 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:2153410 | pubmed:volume | 1042 | lld:pubmed |
| pubmed-article:2153410 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2153410 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2153410 | pubmed:pagination | 132-7 | lld:pubmed |
| pubmed-article:2153410 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:2153410 | pubmed:meshHeading | pubmed-meshheading:2153410-... | lld:pubmed |
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| pubmed-article:2153410 | pubmed:meshHeading | pubmed-meshheading:2153410-... | lld:pubmed |
| pubmed-article:2153410 | pubmed:meshHeading | pubmed-meshheading:2153410-... | lld:pubmed |
| pubmed-article:2153410 | pubmed:meshHeading | pubmed-meshheading:2153410-... | lld:pubmed |
| pubmed-article:2153410 | pubmed:meshHeading | pubmed-meshheading:2153410-... | lld:pubmed |
| pubmed-article:2153410 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2153410 | pubmed:articleTitle | Stimulation of a neutral cholesteryl ester hydrolase by cAMP system in P388D1 macrophages. | lld:pubmed |
| pubmed-article:2153410 | pubmed:affiliation | Department of Medicine, University of California, San Diego, La Jolla. | lld:pubmed |
| pubmed-article:2153410 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2153410 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2153410 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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