Linked Life Data

21532840

Source:http://linkedlifedata.com/resource/pubmed/id/21532840

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pubmed-article:21532840pubmed:dateCreated2011-5-2lld:pubmed
pubmed-article:21532840pubmed:abstractTextRecent epidemiologic evidence supports a role for MUC1 in ovarian carcinogenesis; therefore, we hypothesized that common genetic variation in the genes responsible for glycosylation of MUC1 may influence ovarian cancer risk. In a genome-wide association study of ovarian cancer, we observed an association between a non-synonymous SNP (rs2271077) in the UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosainyltransferase 2 (GALNT2) gene and ovarian cancer risk (p=0.005). We sought to validate the association in four population based ovarian cancer case-control studies collaborating through the Ovarian Cancer Association Consortium. Although rs2271077 was associated with a significantly increased risk (Odds Ratio (OR) = 1.37, 95% Confidence Interval (CI) = 1.06-1.77) in one study with 961 cases and 922 controls, we observed no association in the remaining three studies including 1452 cases and 1954 controls (OR=0.83, 95% CI= 0.66-1.04). Therefore, there appears to be no strong evidence of association between GALNT2 SNP rs2271077 and ovarian cancer risk.lld:pubmed
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pubmed-article:21532840pubmed:authorpubmed-author:CarneyMichael...lld:pubmed
pubmed-article:21532840pubmed:authorpubmed-author:CramerDaniel...lld:pubmed
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pubmed-article:21532840pubmed:authorpubmed-author:VitonisAlliso...lld:pubmed
pubmed-article:21532840pubmed:authorpubmed-author:RamusSusan...lld:pubmed
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pubmed-article:21532840pubmed:authorpubmed-author:Gentry-Mahara...lld:pubmed
pubmed-article:21532840pubmed:authorpubmed-author:PharaohPaul...lld:pubmed
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pubmed-article:21532840pubmed:volume1lld:pubmed
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pubmed-article:21532840pubmed:pagination272-7lld:pubmed
pubmed-article:21532840pubmed:dateRevised2011-7-28lld:pubmed
pubmed-article:21532840pubmed:year2010lld:pubmed
pubmed-article:21532840pubmed:articleTitleA polymorphism in the GALNT2 gene and ovarian cancer risk in four population based case-control studies.lld:pubmed
pubmed-article:21532840pubmed:publicationTypeJournal Articlelld:pubmed