| pubmed-article:21527636 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21527636 | lifeskim:mentions | umls-concept:C0205653 | lld:lifeskim |
| pubmed-article:21527636 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:21527636 | lifeskim:mentions | umls-concept:C1176472 | lld:lifeskim |
| pubmed-article:21527636 | lifeskim:mentions | umls-concept:C0008810 | lld:lifeskim |
| pubmed-article:21527636 | lifeskim:mentions | umls-concept:C0206181 | lld:lifeskim |
| pubmed-article:21527636 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:21527636 | lifeskim:mentions | umls-concept:C0107103 | lld:lifeskim |
| pubmed-article:21527636 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:21527636 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:21527636 | lifeskim:mentions | umls-concept:C0205390 | lld:lifeskim |
| pubmed-article:21527636 | lifeskim:mentions | umls-concept:C0725066 | lld:lifeskim |
| pubmed-article:21527636 | lifeskim:mentions | umls-concept:C2718082 | lld:lifeskim |
| pubmed-article:21527636 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:21527636 | pubmed:dateCreated | 2011-6-13 | lld:pubmed |
| pubmed-article:21527636 | pubmed:abstractText | In adult rat brains, brain-derived neurotrophic factor (BDNF) rhythmically oscillates according to the light-dark cycle and exhibits unique functions in particular brain regions. However, little is known of this subject in juvenile rats. Here, we examined diurnal variation in BDNF and neurotrophin-3 (NT-3) levels in 14-day-old rats. BDNF levels were high in the dark phase and low in the light phase in a majority of brain regions. In contrast, NT-3 levels demonstrated an inverse phase relationship that was limited to the cerebral neocortex, including the visual cortex, and was most prominent on postnatal day 14. An 8-h phase advance of the light-dark cycle and sleep deprivation induced an increase in BDNF levels and a decrease in NT-3 levels in the neocortex, and the former treatment reduced synaptophysin expression and the numbers of synaptophysin-positive presynaptic terminals in cortical layer IV and caused abnormal BDNF and NT-3 rhythms 1 week after treatment. A similar reduction of synaptophysin expression was observed in the cortices of Bdnf gene-deficient mice and Ca(2+)-dependent activator protein for secretion 2 gene-deficient mice with abnormal free-running rhythm and autistic-like phenotypes. In the latter mice, no diurnal variation in BDNF levels was observed. These results indicate that regular rhythms of BDNF and NT-3 are essential for correct cortical network formation in juvenile rodents. | lld:pubmed |
| pubmed-article:21527636 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21527636 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21527636 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21527636 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21527636 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21527636 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21527636 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21527636 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21527636 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:21527636 | pubmed:issn | 1083-351X | lld:pubmed |
| pubmed-article:21527636 | pubmed:author | pubmed-author:FuruichiTeiic... | lld:pubmed |
| pubmed-article:21527636 | pubmed:author | pubmed-author:Katoh-SembaRi... | lld:pubmed |
| pubmed-article:21527636 | pubmed:author | pubmed-author:MatsudaMotoko... | lld:pubmed |
| pubmed-article:21527636 | pubmed:author | pubmed-author:HataYoshioY | lld:pubmed |
| pubmed-article:21527636 | pubmed:author | pubmed-author:IchisakaSatos... | lld:pubmed |
| pubmed-article:21527636 | pubmed:author | pubmed-author:NagataKoh-ich... | lld:pubmed |
| pubmed-article:21527636 | pubmed:author | pubmed-author:MiyazakiNorik... | lld:pubmed |
| pubmed-article:21527636 | pubmed:author | pubmed-author:SadakataTetsu... | lld:pubmed |
| pubmed-article:21527636 | pubmed:author | pubmed-author:NakagawaChiak... | lld:pubmed |
| pubmed-article:21527636 | pubmed:author | pubmed-author:SudoKaoriK | lld:pubmed |
| pubmed-article:21527636 | pubmed:author | pubmed-author:FuruyaAsakoA | lld:pubmed |
| pubmed-article:21527636 | pubmed:author | pubmed-author:HamatakeMichi... | lld:pubmed |
| pubmed-article:21527636 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21527636 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:21527636 | pubmed:volume | 286 | lld:pubmed |
| pubmed-article:21527636 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21527636 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21527636 | pubmed:pagination | 21478-87 | lld:pubmed |
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| pubmed-article:21527636 | pubmed:meshHeading | pubmed-meshheading:21527636... | lld:pubmed |
| pubmed-article:21527636 | pubmed:meshHeading | pubmed-meshheading:21527636... | lld:pubmed |
| pubmed-article:21527636 | pubmed:meshHeading | pubmed-meshheading:21527636... | lld:pubmed |
| pubmed-article:21527636 | pubmed:meshHeading | pubmed-meshheading:21527636... | lld:pubmed |
| pubmed-article:21527636 | pubmed:meshHeading | pubmed-meshheading:21527636... | lld:pubmed |
| pubmed-article:21527636 | pubmed:meshHeading | pubmed-meshheading:21527636... | lld:pubmed |
| pubmed-article:21527636 | pubmed:meshHeading | pubmed-meshheading:21527636... | lld:pubmed |
| pubmed-article:21527636 | pubmed:meshHeading | pubmed-meshheading:21527636... | lld:pubmed |
| pubmed-article:21527636 | pubmed:meshHeading | pubmed-meshheading:21527636... | lld:pubmed |
| pubmed-article:21527636 | pubmed:meshHeading | pubmed-meshheading:21527636... | lld:pubmed |
| pubmed-article:21527636 | pubmed:meshHeading | pubmed-meshheading:21527636... | lld:pubmed |
| pubmed-article:21527636 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21527636 | pubmed:articleTitle | Phase advance of the light-dark cycle perturbs diurnal rhythms of brain-derived neurotrophic factor and neurotrophin-3 protein levels, which reduces synaptophysin-positive presynaptic terminals in the cortex of juvenile rats. | lld:pubmed |
| pubmed-article:21527636 | pubmed:affiliation | Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi 480-0392, Japan. | lld:pubmed |
| pubmed-article:21527636 | pubmed:publicationType | Journal Article | lld:pubmed |
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| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21527636 | lld:entrezgene |
