pubmed-article:21521802 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:21521802 | lifeskim:mentions | umls-concept:C0597032 | lld:lifeskim |
pubmed-article:21521802 | lifeskim:mentions | umls-concept:C0206743 | lld:lifeskim |
pubmed-article:21521802 | lifeskim:mentions | umls-concept:C0007620 | lld:lifeskim |
pubmed-article:21521802 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
pubmed-article:21521802 | lifeskim:mentions | umls-concept:C0431085 | lld:lifeskim |
pubmed-article:21521802 | lifeskim:mentions | umls-concept:C0292369 | lld:lifeskim |
pubmed-article:21521802 | lifeskim:mentions | umls-concept:C1156210 | lld:lifeskim |
pubmed-article:21521802 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
pubmed-article:21521802 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
pubmed-article:21521802 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
pubmed-article:21521802 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
pubmed-article:21521802 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
pubmed-article:21521802 | pubmed:issue | 9 | lld:pubmed |
pubmed-article:21521802 | pubmed:dateCreated | 2011-5-2 | lld:pubmed |
pubmed-article:21521802 | pubmed:abstractText | Rhabdoid tumors (RT) are aggressive pediatric malignancies with poor prognosis. INI1/hSNF5 is a component of the chromatin remodeling SWI/SNF complex and a tumor suppressor deleted in RT. Previous microarray studies indicated that reintroduction of INI1/hSNF5 into RT cells leads to repression of a high degree of mitotic genes including Aurora Kinase A (Aurora A, STK6). Here, we found that INI1/SNF5 represses Aurora A transcription in a cell-type-specific manner. INI1-mediated repression was observed in RT and normal cells but not in non-RT cell lines. Chromatin immunoprecipitation (ChIP) assay indicated that INI1/hSNF5 associates with Aurora A promoter in RT and normal cells but not in non-RT cells. Real-time PCR and immunohistochemical analyses of primary human and mouse RTs harboring mutations in INI1/hSNF5 gene indicated that Aurora A was overexpressed/derepressed in these tumor cells, confirming that INI1/hSNF5 represses Aurora A in vivo. Knockdown of Aurora A impaired cell growth, induced mitotic arrest and aberrant nuclear division leading to decreased survival, and increased cell death and caspase 3/7-mediated apoptosis in RT cells (but not in normal cells). These results indicated that Aurora A is a direct downstream target of INI1/hSNF5-mediated repression in RT cells and that loss of INI1/hSNF5 leads to aberrant overexpression of Aurora A in these tumors, which is required for their survival. We propose that a high degree of Aurora A expression may play a role in aggressive behavior of RTs and that targeting expression or activity of this gene is a novel therapeutic strategy for these tumors. | lld:pubmed |
pubmed-article:21521802 | pubmed:language | eng | lld:pubmed |
pubmed-article:21521802 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:21521802 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:21521802 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:21521802 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:21521802 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:21521802 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:21521802 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:21521802 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:21521802 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:21521802 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:21521802 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:21521802 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:21521802 | pubmed:month | May | lld:pubmed |
pubmed-article:21521802 | pubmed:issn | 1538-7445 | lld:pubmed |
pubmed-article:21521802 | pubmed:author | pubmed-author:KalpanaGanjam... | lld:pubmed |
pubmed-article:21521802 | pubmed:author | pubmed-author:ZagzagDavidD | lld:pubmed |
pubmed-article:21521802 | pubmed:author | pubmed-author:LeeSeungjaeS | lld:pubmed |
pubmed-article:21521802 | pubmed:author | pubmed-author:CimicaVelasco... | lld:pubmed |
pubmed-article:21521802 | pubmed:author | pubmed-author:RamachandraNa... | lld:pubmed |
pubmed-article:21521802 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:21521802 | pubmed:day | 1 | lld:pubmed |
pubmed-article:21521802 | pubmed:volume | 71 | lld:pubmed |
pubmed-article:21521802 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:21521802 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:21521802 | pubmed:pagination | 3225-35 | lld:pubmed |
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pubmed-article:21521802 | pubmed:year | 2011 | lld:pubmed |
pubmed-article:21521802 | pubmed:articleTitle | Aurora A is a repressed effector target of the chromatin remodeling protein INI1/hSNF5 required for rhabdoid tumor cell survival. | lld:pubmed |
pubmed-article:21521802 | pubmed:affiliation | Department of Genetics, Albert Einstein College of Medicine, New York University, New York, NY, USA. | lld:pubmed |
pubmed-article:21521802 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:21521802 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
entrez-gene:6598 | entrezgene:pubmed | pubmed-article:21521802 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21521802 | lld:entrezgene |