| pubmed-article:21519830 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21519830 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:21519830 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:21519830 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:21519830 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:21519830 | pubmed:dateCreated | 2011-6-21 | lld:pubmed |
| pubmed-article:21519830 | pubmed:abstractText | Staphylococcal enterotoxins A (SEA) and B (SEB) are classical models of superantigens (SAg), which induce potent T-cell-stimulating activity by forming complexes with MHC class II molecules on antigen-presenting cells. This large-scale activation of T-cells is accompanied by increased production of cytokines such as interferon-? (IFN-?). Additionally, as we previously reported, IFN-?-producing CD8(+) T cells act as "helper cells," supporting the ability of dendritic cells to produce interleukin-12 (IL-12)p70. Here, we show that DC pulsed with SAg promote the enhancement of anti-tumor immunity. Murine bone marrow-derived dendritic cells (DC) were pulsed with OVA(257-264) (SIINFEKL), which is an H-2Kb target epitope of EG7 [ovalbumin (OVA)-expressing EL4] cell lines, in the presence of SEA and SEB and were subcutaneously injected into naïve C57BL/6 mice. SAg plus OVA(257-264)-pulsed DC vaccine strongly enhanced peptide-specific CD8(+) T cells exhibiting OVA(257-264)-specific cytotoxic activity and IFN-? production, leading to the induction of protective immunity against EG7 tumors. Furthermore, cyclophosphamide (CY) added to SAg plus tumor-antigens (OVA(257-264), tumor lysate, or TRP-2) pulsed DC immunization markedly enhanced tumor-specific T-cell expansion and had a significant therapeutic effect against various tumors (EG7, 2LL, and B16). Superantigens are potential candidates for enhancing tumor immunity in DC vaccines. | lld:pubmed |
| pubmed-article:21519830 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21519830 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21519830 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21519830 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21519830 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21519830 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21519830 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21519830 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21519830 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21519830 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21519830 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21519830 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21519830 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21519830 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21519830 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21519830 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:21519830 | pubmed:issn | 1432-0851 | lld:pubmed |
| pubmed-article:21519830 | pubmed:author | pubmed-author:KatoMasatoM | lld:pubmed |
| pubmed-article:21519830 | pubmed:author | pubmed-author:NakamuraHirot... | lld:pubmed |
| pubmed-article:21519830 | pubmed:author | pubmed-author:KalinskiPawel... | lld:pubmed |
| pubmed-article:21519830 | pubmed:author | pubmed-author:SeoNaohiroN | lld:pubmed |
| pubmed-article:21519830 | pubmed:author | pubmed-author:NagataToshiT | lld:pubmed |
| pubmed-article:21519830 | pubmed:author | pubmed-author:KoideYukioY | lld:pubmed |
| pubmed-article:21519830 | pubmed:author | pubmed-author:ChidaKingoK | lld:pubmed |
| pubmed-article:21519830 | pubmed:author | pubmed-author:SudaTakafumiT | lld:pubmed |
| pubmed-article:21519830 | pubmed:author | pubmed-author:NakamuraYutar... | lld:pubmed |
| pubmed-article:21519830 | pubmed:author | pubmed-author:InuiNaokiN | lld:pubmed |
| pubmed-article:21519830 | pubmed:author | pubmed-author:OzawaYuichiY | lld:pubmed |
| pubmed-article:21519830 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21519830 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:21519830 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21519830 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21519830 | pubmed:pagination | 1029-38 | lld:pubmed |
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| pubmed-article:21519830 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21519830 | pubmed:articleTitle | Enhanced anti-tumor immunity by superantigen-pulsed dendritic cells. | lld:pubmed |
| pubmed-article:21519830 | pubmed:affiliation | Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Japan. | lld:pubmed |
| pubmed-article:21519830 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21519830 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
