| pubmed-article:21513770 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21513770 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:21513770 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:21513770 | lifeskim:mentions | umls-concept:C1149848 | lld:lifeskim |
| pubmed-article:21513770 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:21513770 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:21513770 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:21513770 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:21513770 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:21513770 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:21513770 | pubmed:dateCreated | 2011-5-16 | lld:pubmed |
| pubmed-article:21513770 | pubmed:abstractText | Methylmercury (MeHg) is a neurotoxin capable of causing severe damage to the CNS, especially in the developing fetus. Glia in the CNS release a number of cytokines that are important for proper CNS development and function. We reported earlier that MeHg could induce interleukin-6 (IL-6) release in primary mouse glia. This finding is significant considering previous reports indicating that sustained IL-6 exposure could be detrimental to cerebellar granule neurons, one of the major cellular targets of MeHg cytotoxicity. By using pharmacological antagonists against phophatidycholine- and phosphoinositol-specific phospholipase C, the current study indicated that phospholipase C activity was necessary for MeHg-induced IL-6 release. Results from pharmacological antagonists further suggested that the calcium signaling initiated by phospholipase C appeared essential for this event. In contrast, protein kinase C activity did not appear to be important. Even though mitogen-activated protein kinases were important for IL-6 release in some experimental systems, these enzymes did not appear to be required for MeHg-induced IL-6 release in glia. Based on these data and those reported by us and others, there is a possibility that MeHg-induced phospholipase C activation initiates a calcium signaling that causes phospholipase A(2) activation. This, in turn, leads to arachidonic acid and lysophosphatidyl choline generation, both of which are potent inducers for IL-6 release. | lld:pubmed |
| pubmed-article:21513770 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21513770 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21513770 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21513770 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21513770 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21513770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21513770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21513770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21513770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21513770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21513770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21513770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21513770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21513770 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21513770 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:21513770 | pubmed:issn | 1872-7972 | lld:pubmed |
| pubmed-article:21513770 | pubmed:author | pubmed-author:ChangJason... | lld:pubmed |
| pubmed-article:21513770 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:21513770 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21513770 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:21513770 | pubmed:volume | 496 | lld:pubmed |
| pubmed-article:21513770 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21513770 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21513770 | pubmed:pagination | 152-6 | lld:pubmed |
| pubmed-article:21513770 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:21513770 | pubmed:meshHeading | pubmed-meshheading:21513770... | lld:pubmed |
| pubmed-article:21513770 | pubmed:meshHeading | pubmed-meshheading:21513770... | lld:pubmed |
| pubmed-article:21513770 | pubmed:meshHeading | pubmed-meshheading:21513770... | lld:pubmed |
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| pubmed-article:21513770 | pubmed:meshHeading | pubmed-meshheading:21513770... | lld:pubmed |
| pubmed-article:21513770 | pubmed:meshHeading | pubmed-meshheading:21513770... | lld:pubmed |
| pubmed-article:21513770 | pubmed:meshHeading | pubmed-meshheading:21513770... | lld:pubmed |
| pubmed-article:21513770 | pubmed:meshHeading | pubmed-meshheading:21513770... | lld:pubmed |
| pubmed-article:21513770 | pubmed:meshHeading | pubmed-meshheading:21513770... | lld:pubmed |
| pubmed-article:21513770 | pubmed:meshHeading | pubmed-meshheading:21513770... | lld:pubmed |
| pubmed-article:21513770 | pubmed:meshHeading | pubmed-meshheading:21513770... | lld:pubmed |
| pubmed-article:21513770 | pubmed:meshHeading | pubmed-meshheading:21513770... | lld:pubmed |
| pubmed-article:21513770 | pubmed:meshHeading | pubmed-meshheading:21513770... | lld:pubmed |
| pubmed-article:21513770 | pubmed:meshHeading | pubmed-meshheading:21513770... | lld:pubmed |
| pubmed-article:21513770 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21513770 | pubmed:articleTitle | Methylmercury-induced IL-6 release requires phospholipase C activities. | lld:pubmed |
| pubmed-article:21513770 | pubmed:affiliation | Department of Neurobiology and Developmental Sciences, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. changjasony@uams.edu | lld:pubmed |
| pubmed-article:21513770 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21513770 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
