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pubmed-article:21509165pubmed:dateCreated2011-4-21lld:pubmed
pubmed-article:21509165pubmed:abstractTextHigh-dose methotrexate (MTX) chemotherapy extends the duration of hospitalization and introduces the risks of serious complications related to delayed MTX excretion. The treatment of delayed MTX excretion is largely dependent on invasive measures such as hemodialysis because the clinical data regarding the efficacy or safety of carboxypetidase G(2) is limited. We report here on the cases of two pediatric osteosarcoma patients with delayed MTX excretion and who were successfully managed using supportive measures. Potential life-threatening complications were prevented by administering high doses of leucovorin.lld:pubmed
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pubmed-article:21509165pubmed:statusPubMed-not-MEDLINElld:pubmed
pubmed-article:21509165pubmed:monthMarlld:pubmed
pubmed-article:21509165pubmed:issn2005-9256lld:pubmed
pubmed-article:21509165pubmed:authorpubmed-author:KimDong HoDHlld:pubmed
pubmed-article:21509165pubmed:authorpubmed-author:KimDong...lld:pubmed
pubmed-article:21509165pubmed:authorpubmed-author:LeeJin...lld:pubmed
pubmed-article:21509165pubmed:authorpubmed-author:LeeKang MinKMlld:pubmed
pubmed-article:21509165pubmed:authorpubmed-author:LeeHyeon...lld:pubmed
pubmed-article:21509165pubmed:authorpubmed-author:LimJung SubJSlld:pubmed
pubmed-article:21509165pubmed:authorpubmed-author:LeeJun AhJAlld:pubmed
pubmed-article:21509165pubmed:authorpubmed-author:LeeHee WooHWlld:pubmed
pubmed-article:21509165pubmed:authorpubmed-author:ChoJoongbumJlld:pubmed
pubmed-article:21509165pubmed:authorpubmed-author:KimSeung...lld:pubmed
pubmed-article:21509165pubmed:issnTypeElectroniclld:pubmed
pubmed-article:21509165pubmed:volume43lld:pubmed
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pubmed-article:21509165pubmed:pagination67-70lld:pubmed
pubmed-article:21509165pubmed:dateRevised2011-7-28lld:pubmed
pubmed-article:21509165pubmed:year2011lld:pubmed
pubmed-article:21509165pubmed:articleTitleTwo pediatric osteosarcoma cases with delayed methotrexate excretion: its clinical course and management.lld:pubmed
pubmed-article:21509165pubmed:affiliationDepartment of Pediatrics, Korea Cancer Center Hospital, Seoul, Korea.lld:pubmed
pubmed-article:21509165pubmed:publicationTypeJournal Articlelld:pubmed