| pubmed-article:21507972 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21507972 | lifeskim:mentions | umls-concept:C0206419 | lld:lifeskim |
| pubmed-article:21507972 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:21507972 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:21507972 | lifeskim:mentions | umls-concept:C0679199 | lld:lifeskim |
| pubmed-article:21507972 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:21507972 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:21507972 | pubmed:dateCreated | 2011-6-10 | lld:pubmed |
| pubmed-article:21507972 | pubmed:abstractText | Coronaviruses are a family of enveloped single-stranded positive-sense RNA viruses causing respiratory, enteric, and neurologic diseases in mammals and fowl. Human coronaviruses are recognized to cause up to a third of common colds and are suspected to be involved in enteric and neurologic diseases. Coronavirus replication involves the generation of nested subgenomic mRNAs (sgmRNAs) with a common capped 5' leader sequence. The translation of most of the sgmRNAs is thought to be cap dependent and displays a requirement for eukaryotic initiation factor 4F (eIF4F), a heterotrimeric complex needed for the recruitment of 40S ribosomes. We recently reported on an ultrahigh-throughput screen to discover compounds that inhibit eIF4F activity by blocking the interaction of two of its subunits (R. Cencic et al., Proc. Natl. Acad. Sci. U. S. A. 108:1046-1051, 2011). Herein we describe a molecule from this screen that prevents the interaction between eIF4E (the cap-binding protein) and eIF4G (a large scaffolding protein), inhibiting cap-dependent translation. This inhibitor significantly decreased human coronavirus 229E (HCoV-229E) replication, reducing the percentage of infected cells and intra- and extracellular infectious virus titers. Our results support the strategy of targeting the eIF4F complex to block coronavirus infection. | lld:pubmed |
| pubmed-article:21507972 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21507972 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21507972 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21507972 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21507972 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21507972 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21507972 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21507972 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21507972 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21507972 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21507972 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21507972 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21507972 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21507972 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21507972 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:21507972 | pubmed:issn | 1098-5514 | lld:pubmed |
| pubmed-article:21507972 | pubmed:author | pubmed-author:VajdaSandorS | lld:pubmed |
| pubmed-article:21507972 | pubmed:author | pubmed-author:PelletierJerr... | lld:pubmed |
| pubmed-article:21507972 | pubmed:author | pubmed-author:HallDavid RDR | lld:pubmed |
| pubmed-article:21507972 | pubmed:author | pubmed-author:DesforgesMarc... | lld:pubmed |
| pubmed-article:21507972 | pubmed:author | pubmed-author:TalbotPierre... | lld:pubmed |
| pubmed-article:21507972 | pubmed:author | pubmed-author:FuHaianH | lld:pubmed |
| pubmed-article:21507972 | pubmed:author | pubmed-author:DingledineRay... | lld:pubmed |
| pubmed-article:21507972 | pubmed:author | pubmed-author:MinJaekiJ | lld:pubmed |
| pubmed-article:21507972 | pubmed:author | pubmed-author:CencicReginaR | lld:pubmed |
| pubmed-article:21507972 | pubmed:author | pubmed-author:KozakovDimaD | lld:pubmed |
| pubmed-article:21507972 | pubmed:author | pubmed-author:DuYuhongY | lld:pubmed |
| pubmed-article:21507972 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21507972 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:21507972 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21507972 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21507972 | pubmed:pagination | 6381-9 | lld:pubmed |
| pubmed-article:21507972 | pubmed:meshHeading | pubmed-meshheading:21507972... | lld:pubmed |
| pubmed-article:21507972 | pubmed:meshHeading | pubmed-meshheading:21507972... | lld:pubmed |
| pubmed-article:21507972 | pubmed:meshHeading | pubmed-meshheading:21507972... | lld:pubmed |
| pubmed-article:21507972 | pubmed:meshHeading | pubmed-meshheading:21507972... | lld:pubmed |
| pubmed-article:21507972 | pubmed:meshHeading | pubmed-meshheading:21507972... | lld:pubmed |
| pubmed-article:21507972 | pubmed:meshHeading | pubmed-meshheading:21507972... | lld:pubmed |
| pubmed-article:21507972 | pubmed:meshHeading | pubmed-meshheading:21507972... | lld:pubmed |
| pubmed-article:21507972 | pubmed:meshHeading | pubmed-meshheading:21507972... | lld:pubmed |
| pubmed-article:21507972 | pubmed:meshHeading | pubmed-meshheading:21507972... | lld:pubmed |
| pubmed-article:21507972 | pubmed:meshHeading | pubmed-meshheading:21507972... | lld:pubmed |
| pubmed-article:21507972 | pubmed:meshHeading | pubmed-meshheading:21507972... | lld:pubmed |
| pubmed-article:21507972 | pubmed:meshHeading | pubmed-meshheading:21507972... | lld:pubmed |
| pubmed-article:21507972 | pubmed:meshHeading | pubmed-meshheading:21507972... | lld:pubmed |
| pubmed-article:21507972 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21507972 | pubmed:articleTitle | Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication. | lld:pubmed |
| pubmed-article:21507972 | pubmed:affiliation | McIntyre Medical Sciences Building, Rm. 810, 3655 Promenade Sir William Osler, McGill University, Montreal, Quebec, Canada H3G 1Y6. | lld:pubmed |
| pubmed-article:21507972 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21507972 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21507972 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
