| pubmed-article:21504063 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21504063 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:21504063 | lifeskim:mentions | umls-concept:C0009924 | lld:lifeskim |
| pubmed-article:21504063 | lifeskim:mentions | umls-concept:C0024485 | lld:lifeskim |
| pubmed-article:21504063 | lifeskim:mentions | umls-concept:C1881134 | lld:lifeskim |
| pubmed-article:21504063 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:21504063 | lifeskim:mentions | umls-concept:C1138408 | lld:lifeskim |
| pubmed-article:21504063 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:21504063 | pubmed:dateCreated | 2011-4-19 | lld:pubmed |
| pubmed-article:21504063 | pubmed:abstractText | We quantify here, for the first time, the intracellular uptake (J774A.1 murine macrophage cells) of gadolinium-loaded ultra-short single-walled carbon nanotubes (gadonanotubes or GNTs) in a 3 T MRI scanner using R(2) and R(2)* mapping in vitro. GNT-labeled cells exhibited high and linear changes in net transverse relaxations (?R(2) and ?R?2*) with increasing cell concentration. The measured ?R(2)* were about three to four times greater than the respective ?R(2) for each cell concentration. The intracellular uptake of GNTs was validated with inductively coupled plasma optical emission spectrometry (ICP-OES), indicating an average cellular uptake of 0.44?±?0.09?pg Gd per cell or 1.69?×?10(9) Gd(3+) ions per cell. Cell proliferation MTS assays demonstrated that the cells were effectively labeled, without cytotoxicity, for GNTs concentrations ?28?µM Gd. In vivo relaxometry of a subcutaneously-injected GNT-labeled cell pellet in a mouse was also demonstrated at 3 T. Finally, the pronounced R(2)* effect of GNT-labeled cells enabled successful in vitro visualization of labeled cells at 9.4 T. | lld:pubmed |
| pubmed-article:21504063 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21504063 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21504063 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21504063 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21504063 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21504063 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21504063 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21504063 | pubmed:issn | 1555-4317 | lld:pubmed |
| pubmed-article:21504063 | pubmed:author | pubmed-author:ZhaoHongH | lld:pubmed |
| pubmed-article:21504063 | pubmed:author | pubmed-author:WilsonLon JLJ | lld:pubmed |
| pubmed-article:21504063 | pubmed:author | pubmed-author:LamEdmund YEY | lld:pubmed |
| pubmed-article:21504063 | pubmed:author | pubmed-author:WongKelvin... | lld:pubmed |
| pubmed-article:21504063 | pubmed:author | pubmed-author:WongStephen... | lld:pubmed |
| pubmed-article:21504063 | pubmed:author | pubmed-author:TangAnnie MAM | lld:pubmed |
| pubmed-article:21504063 | pubmed:author | pubmed-author:AnantaJeyaram... | lld:pubmed |
| pubmed-article:21504063 | pubmed:author | pubmed-author:CisnerosBrand... | lld:pubmed |
| pubmed-article:21504063 | pubmed:copyrightInfo | Copyright © 2010 John Wiley & Sons, Ltd. | lld:pubmed |
| pubmed-article:21504063 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21504063 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:21504063 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21504063 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21504063 | pubmed:pagination | 93-9 | lld:pubmed |
| pubmed-article:21504063 | pubmed:meshHeading | pubmed-meshheading:21504063... | lld:pubmed |
| pubmed-article:21504063 | pubmed:meshHeading | pubmed-meshheading:21504063... | lld:pubmed |
| pubmed-article:21504063 | pubmed:meshHeading | pubmed-meshheading:21504063... | lld:pubmed |
| pubmed-article:21504063 | pubmed:meshHeading | pubmed-meshheading:21504063... | lld:pubmed |
| pubmed-article:21504063 | pubmed:meshHeading | pubmed-meshheading:21504063... | lld:pubmed |
| pubmed-article:21504063 | pubmed:meshHeading | pubmed-meshheading:21504063... | lld:pubmed |
| pubmed-article:21504063 | pubmed:meshHeading | pubmed-meshheading:21504063... | lld:pubmed |
| pubmed-article:21504063 | pubmed:meshHeading | pubmed-meshheading:21504063... | lld:pubmed |
| pubmed-article:21504063 | pubmed:articleTitle | Cellular uptake and imaging studies of gadolinium-loaded single-walled carbon nanotubes as MRI contrast agents. | lld:pubmed |
| pubmed-article:21504063 | pubmed:affiliation | Bioengineering and Bioinformatics Program, The Methodist Hospital Research Institute & Weill Cornell Medical College Houston, TX 77030, USA. | lld:pubmed |
| pubmed-article:21504063 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21504063 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:21504063 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
