Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1).

Source:http://linkedlifedata.com/resource/pubmed/id/21502314

J. Biol. Chem. 2011 Jun 3 286 22 19229-36

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PMID
21502314