Linked Life Data

21489413

Source:http://linkedlifedata.com/resource/pubmed/id/21489413

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pubmed-article:21489413pubmed:abstractTextThe antibody 13B8.2, which is directed against the CDR3-like loop on the D1 domain of CD4, induces CD4/ZAP-70 reorganization and ceramide release in membrane rafts. Here, we investigated whether CD4/ZAP-70 compartmentalization could be mediated by an effect of 13B8.2 on the Carma1-Bcl10-MALT1 complex in membrane rafts. We report that treatment of CD3/CD28-activated Jurkat T cells with 13B8.2, but not rituximab, excluded Carma1-Bcl10-MALT1 proteins from GM1(+) membrane rafts and concomitantly decreased NF-?B activation. Fluorescence confocal imaging confirmed that Carma1-Bcl10 and Carma1-MALT1 co-patching, observed in GM1(+) membrane rafts following CD3/CD28 activation, were abrogated after a 24h-treatment with 13B8.2. The CD4/ZAP-70 compartmentalization in membrane rafts induced by 13B8.2 is thus related to Carma1-Bcl10-MALT1 raft exclusion.lld:pubmed
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pubmed-article:21489413pubmed:statusMEDLINElld:pubmed
pubmed-article:21489413pubmed:issn1090-2163lld:pubmed
pubmed-article:21489413pubmed:authorpubmed-author:ChardèsThierr...lld:pubmed
pubmed-article:21489413pubmed:authorpubmed-author:PèlegrinAndré...lld:pubmed
pubmed-article:21489413pubmed:authorpubmed-author:ChentoufMyria...lld:pubmed
pubmed-article:21489413pubmed:authorpubmed-author:RigoMaximeMlld:pubmed
pubmed-article:21489413pubmed:copyrightInfoCopyright © 2011 Elsevier Inc. All rights reserved.lld:pubmed
pubmed-article:21489413pubmed:issnTypeElectroniclld:pubmed
pubmed-article:21489413pubmed:volume270lld:pubmed
pubmed-article:21489413pubmed:ownerNLMlld:pubmed
pubmed-article:21489413pubmed:authorsCompleteYlld:pubmed
pubmed-article:21489413pubmed:pagination40-6lld:pubmed
pubmed-article:21489413pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:21489413pubmed:year2011lld:pubmed
pubmed-article:21489413pubmed:articleTitleCD4 ligation excludes the Carma1-Bcl10-MALT1 complex from GM1-positive membrane rafts in CD3/CD28 activated T cells.lld:pubmed
pubmed-article:21489413pubmed:affiliationIRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier F-34298, France.lld:pubmed
pubmed-article:21489413pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21489413pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed