| pubmed-article:21482705 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21482705 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:21482705 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:21482705 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:21482705 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:21482705 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:21482705 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:21482705 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:21482705 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:21482705 | pubmed:dateCreated | 2011-6-17 | lld:pubmed |
| pubmed-article:21482705 | pubmed:abstractText | The inhibitor of Bruton tyrosine kinase ? (IBtk?) is a negative regulator of the Bruton tyrosine kinase (Btk), which plays a major role in B-cell differentiation; however, the mechanisms of IBtk?-mediated regulation of Btk are unknown. Here we report that B-cell receptor (BCR) triggering caused serine-phosphorylation of IBtk? at protein kinase C consensus sites and dissociation from Btk. By liquid chromatography and mass-mass spectrometry and functional analysis, we identified IBtk?-S87 and -S90 as the critical amino acid residues that regulate the IBtk? binding affinity to Btk. Consistently, the mutants IBtk? carrying S87A and S90A mutations bound constitutively to Btk and down-regulated Ca(2+) fluxes and NF-?B activation on BCR triggering. Accordingly, spleen B cells from Ibtk?(-/-) mice showed an increased activation of Btk, as evaluated by Y551-phosphorylation and sustained Ca(2+) mobilization on BCR engagement. These findings identify a novel pathway of Btk regulation via protein kinase C phosphorylation of IBtk?. | lld:pubmed |
| pubmed-article:21482705 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21482705 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21482705 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:21482705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21482705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21482705 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21482705 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:21482705 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:21482705 | pubmed:author | pubmed-author:QuintoIleanaI | lld:pubmed |
| pubmed-article:21482705 | pubmed:author | pubmed-author:ScalaGiuseppe... | lld:pubmed |
| pubmed-article:21482705 | pubmed:author | pubmed-author:JandaElzbieta... | lld:pubmed |
| pubmed-article:21482705 | pubmed:author | pubmed-author:GaspariMarcoM | lld:pubmed |
| pubmed-article:21482705 | pubmed:author | pubmed-author:VerheijElwinE | lld:pubmed |
| pubmed-article:21482705 | pubmed:author | pubmed-author:BrittiDomenic... | lld:pubmed |
| pubmed-article:21482705 | pubmed:author | pubmed-author:PalmieriCamil... | lld:pubmed |
| pubmed-article:21482705 | pubmed:author | pubmed-author:RossiAnnalisa... | lld:pubmed |
| pubmed-article:21482705 | pubmed:author | pubmed-author:FiumeGiuseppe... | lld:pubmed |
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| pubmed-article:21482705 | pubmed:author | pubmed-author:PisanoAntonio... | lld:pubmed |
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| pubmed-article:21482705 | pubmed:author | pubmed-author:Di... | lld:pubmed |
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| pubmed-article:21482705 | pubmed:author | pubmed-author:NevoloMariaM | lld:pubmed |
| pubmed-article:21482705 | pubmed:author | pubmed-author:LavecchiaLuca... | lld:pubmed |
| pubmed-article:21482705 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21482705 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:21482705 | pubmed:volume | 117 | lld:pubmed |
| pubmed-article:21482705 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21482705 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21482705 | pubmed:pagination | 6520-31 | lld:pubmed |
| pubmed-article:21482705 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
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| pubmed-article:21482705 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21482705 | pubmed:articleTitle | Btk regulation in human and mouse B cells via protein kinase C phosphorylation of IBtk?. | lld:pubmed |
| pubmed-article:21482705 | pubmed:affiliation | Department of Experimental and Clinical Medicine, University of Catanzaro Magna Graecia, Catanzaro, Italy. | lld:pubmed |
| pubmed-article:21482705 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21482705 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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