| pubmed-article:21482359 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21482359 | lifeskim:mentions | umls-concept:C0039729 | lld:lifeskim |
| pubmed-article:21482359 | lifeskim:mentions | umls-concept:C0012621 | lld:lifeskim |
| pubmed-article:21482359 | lifeskim:mentions | umls-concept:C0014553 | lld:lifeskim |
| pubmed-article:21482359 | lifeskim:mentions | umls-concept:C1413059 | lld:lifeskim |
| pubmed-article:21482359 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:21482359 | lifeskim:mentions | umls-concept:C1511545 | lld:lifeskim |
| pubmed-article:21482359 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:21482359 | pubmed:dateCreated | 2011-4-12 | lld:pubmed |
| pubmed-article:21482359 | pubmed:abstractText | Neurons of the reticular thalamus (RT) display oscillatory burst discharges that are believed to be critical for thalamocortical network oscillations related to absence epilepsy. Ca²+-dependent mechanisms underlie such oscillatory discharges. However, involvement of high-voltage activated (HVA) Ca²+ channels in this process has been discounted. We examined this issue closely using mice deficient for the HVA Ca(v)2.3 channels. In brain slices of Ca(v)2.3?/?, a hyperpolarizing current injection initiated a low-threshold burst of spikes in RT neurons; however, subsequent oscillatory burst discharges were severely suppressed, with a significantly reduced slow afterhyperpolarization (AHP). Consequently, the lack of Ca(v)2.3 resulted in a marked decrease in the sensitivity of the animal to ?-butyrolactone-induced absence epilepsy. Local blockade of Ca(v)2.3 channels in the RT mimicked the results of Ca(v)2.3?/? mice. These results provide strong evidence that Ca(v)2.3 channels are critical for oscillatory burst discharges in RT neurons and for the expression of absence epilepsy. | lld:pubmed |
| pubmed-article:21482359 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21482359 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21482359 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21482359 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21482359 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21482359 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21482359 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21482359 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21482359 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21482359 | pubmed:issn | 1097-4199 | lld:pubmed |
| pubmed-article:21482359 | pubmed:author | pubmed-author:ShinHee-SupHS | lld:pubmed |
| pubmed-article:21482359 | pubmed:author | pubmed-author:LeeC JustinCJ | lld:pubmed |
| pubmed-article:21482359 | pubmed:author | pubmed-author:ChoiJee... | lld:pubmed |
| pubmed-article:21482359 | pubmed:author | pubmed-author:CheongEunjiE | lld:pubmed |
| pubmed-article:21482359 | pubmed:author | pubmed-author:ZamanTariqT | lld:pubmed |
| pubmed-article:21482359 | pubmed:author | pubmed-author:PaydarAfshinA | lld:pubmed |
| pubmed-article:21482359 | pubmed:author | pubmed-author:LeeKyoobinK | lld:pubmed |
| pubmed-article:21482359 | pubmed:author | pubmed-author:ParkCheongdah... | lld:pubmed |
| pubmed-article:21482359 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:21482359 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21482359 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:21482359 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:21482359 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21482359 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21482359 | pubmed:pagination | 95-108 | lld:pubmed |
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| pubmed-article:21482359 | pubmed:meshHeading | pubmed-meshheading:21482359... | lld:pubmed |
| pubmed-article:21482359 | pubmed:meshHeading | pubmed-meshheading:21482359... | lld:pubmed |
| pubmed-article:21482359 | pubmed:meshHeading | pubmed-meshheading:21482359... | lld:pubmed |
| pubmed-article:21482359 | pubmed:meshHeading | pubmed-meshheading:21482359... | lld:pubmed |
| pubmed-article:21482359 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21482359 | pubmed:articleTitle | Cav2.3 channels are critical for oscillatory burst discharges in the reticular thalamus and absence epilepsy. | lld:pubmed |
| pubmed-article:21482359 | pubmed:affiliation | Center for Neural Science, Korea Institute of Science and Technology (KIST), Seoul 136-791, Korea. | lld:pubmed |
| pubmed-article:21482359 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21482359 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:21482359 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:777 | entrezgene:pubmed | pubmed-article:21482359 | lld:entrezgene |
| entrez-gene:12290 | entrezgene:pubmed | pubmed-article:21482359 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21482359 | lld:entrezgene |
