| pubmed-article:21471236 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21471236 | lifeskim:mentions | umls-concept:C0042776 | lld:lifeskim |
| pubmed-article:21471236 | lifeskim:mentions | umls-concept:C0026783 | lld:lifeskim |
| pubmed-article:21471236 | lifeskim:mentions | umls-concept:C0042765 | lld:lifeskim |
| pubmed-article:21471236 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:21471236 | lifeskim:mentions | umls-concept:C0040711 | lld:lifeskim |
| pubmed-article:21471236 | lifeskim:mentions | umls-concept:C0012632 | lld:lifeskim |
| pubmed-article:21471236 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:21471236 | lifeskim:mentions | umls-concept:C0017260 | lld:lifeskim |
| pubmed-article:21471236 | lifeskim:mentions | umls-concept:C0598629 | lld:lifeskim |
| pubmed-article:21471236 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:21471236 | pubmed:dateCreated | 2011-5-20 | lld:pubmed |
| pubmed-article:21471236 | pubmed:abstractText | Deletion of the small hydrophobic (SH) protein of certain paramyxoviruses has been found to result in attenuation, suggesting that the SH protein is a virulence factor. To investigate the role of the mumps virus (MuV) SH protein in virulence, multiple stop codons were introduced into the open reading frame (ORF) of a MuV molecular clone (r88-1961(SHstop)), preserving genome structure but precluding production of the SH protein. No differences in neurovirulence were seen between the wild-type and the SH(stop) viruses. In contrast, upon deletion of the SH gene, significant neuroattenuation was observed. These data indicate that the MuV SH protein is not a neurovirulence factor and highlight the importance of distinguishing gene deletion effects from protein-specific effects. | lld:pubmed |
| pubmed-article:21471236 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21471236 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21471236 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21471236 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21471236 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21471236 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21471236 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21471236 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:21471236 | pubmed:issn | 1098-5514 | lld:pubmed |
| pubmed-article:21471236 | pubmed:author | pubmed-author:DuprexWilliam... | lld:pubmed |
| pubmed-article:21471236 | pubmed:author | pubmed-author:SauderChristi... | lld:pubmed |
| pubmed-article:21471236 | pubmed:author | pubmed-author:RubinStevenS | lld:pubmed |
| pubmed-article:21471236 | pubmed:author | pubmed-author:MalikTahirT | lld:pubmed |
| pubmed-article:21471236 | pubmed:author | pubmed-author:ZhangCherylC | lld:pubmed |
| pubmed-article:21471236 | pubmed:author | pubmed-author:ShegogueCandi... | lld:pubmed |
| pubmed-article:21471236 | pubmed:author | pubmed-author:WernerKellieK | lld:pubmed |
| pubmed-article:21471236 | pubmed:author | pubmed-author:NgoLaurieL | lld:pubmed |
| pubmed-article:21471236 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21471236 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:21471236 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21471236 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21471236 | pubmed:pagination | 6082-5 | lld:pubmed |
| pubmed-article:21471236 | pubmed:meshHeading | pubmed-meshheading:21471236... | lld:pubmed |
| pubmed-article:21471236 | pubmed:meshHeading | pubmed-meshheading:21471236... | lld:pubmed |
| pubmed-article:21471236 | pubmed:meshHeading | pubmed-meshheading:21471236... | lld:pubmed |
| pubmed-article:21471236 | pubmed:meshHeading | pubmed-meshheading:21471236... | lld:pubmed |
| pubmed-article:21471236 | pubmed:meshHeading | pubmed-meshheading:21471236... | lld:pubmed |
| pubmed-article:21471236 | pubmed:meshHeading | pubmed-meshheading:21471236... | lld:pubmed |
| pubmed-article:21471236 | pubmed:meshHeading | pubmed-meshheading:21471236... | lld:pubmed |
| pubmed-article:21471236 | pubmed:meshHeading | pubmed-meshheading:21471236... | lld:pubmed |
| pubmed-article:21471236 | pubmed:meshHeading | pubmed-meshheading:21471236... | lld:pubmed |
| pubmed-article:21471236 | pubmed:meshHeading | pubmed-meshheading:21471236... | lld:pubmed |
| pubmed-article:21471236 | pubmed:meshHeading | pubmed-meshheading:21471236... | lld:pubmed |
| pubmed-article:21471236 | pubmed:meshHeading | pubmed-meshheading:21471236... | lld:pubmed |
| pubmed-article:21471236 | pubmed:meshHeading | pubmed-meshheading:21471236... | lld:pubmed |
| pubmed-article:21471236 | pubmed:meshHeading | pubmed-meshheading:21471236... | lld:pubmed |
| pubmed-article:21471236 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21471236 | pubmed:articleTitle | Discrimination of mumps virus small hydrophobic gene deletion effects from gene translation effects on virus virulence. | lld:pubmed |
| pubmed-article:21471236 | pubmed:affiliation | DVP/Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA. tahir.malik@fda.hhs.gov | lld:pubmed |
| pubmed-article:21471236 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21471236 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:21471236 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| entrez-gene:1489767 | entrezgene:pubmed | pubmed-article:21471236 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21471236 | lld:entrezgene |
