| pubmed-article:21457648 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21457648 | lifeskim:mentions | umls-concept:C0080129 | lld:lifeskim |
| pubmed-article:21457648 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:21457648 | lifeskim:mentions | umls-concept:C1749472 | lld:lifeskim |
| pubmed-article:21457648 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:21457648 | lifeskim:mentions | umls-concept:C1417504 | lld:lifeskim |
| pubmed-article:21457648 | lifeskim:mentions | umls-concept:C1264633 | lld:lifeskim |
| pubmed-article:21457648 | lifeskim:mentions | umls-concept:C0439201 | lld:lifeskim |
| pubmed-article:21457648 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:21457648 | lifeskim:mentions | umls-concept:C1140108 | lld:lifeskim |
| pubmed-article:21457648 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:21457648 | pubmed:dateCreated | 2011-4-4 | lld:pubmed |
| pubmed-article:21457648 | pubmed:abstractText | The essential role of MCM 2-7 proteins in the initiation of DNA replication in all eukaryotes is well known. Their role in replication elongation is supported by numerous studies, but there is still a knowledge gap in this respect. Even though biochemical studies have established an association of MCM proteins with replication forks, previous immunofluorescence studies in mammalian cells have suggested that MCM 2-7 proteins are displaced after replication initiation from sites of DNA replication. Therefore, we used a robust statistical method to more precisely analyse immunofluorescence localization of MCM 2 proteins with respect to the DNA replication foci. We show that despite the predominantly different localization of MCM 2 and replication signals, there is still a small but significant fraction of MCM 2 proteins that co-localize with DNA replication foci during most of S phase. The fluorescence localization of the MCM 2 proteins and DNA replication may thus reflect an active function of MCM 2 proteins associated with the replication foci and partially explain one facet of the "MCM paradox". | lld:pubmed |
| pubmed-article:21457648 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21457648 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21457648 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21457648 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21457648 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21457648 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21457648 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21457648 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21457648 | pubmed:issn | 0015-5500 | lld:pubmed |
| pubmed-article:21457648 | pubmed:author | pubmed-author:CardosoM CMC | lld:pubmed |
| pubmed-article:21457648 | pubmed:author | pubmed-author:JuddSS | lld:pubmed |
| pubmed-article:21457648 | pubmed:author | pubmed-author:MašataMM | lld:pubmed |
| pubmed-article:21457648 | pubmed:author | pubmed-author:RaškaOO | lld:pubmed |
| pubmed-article:21457648 | pubmed:author | pubmed-author:RaškaII | lld:pubmed |
| pubmed-article:21457648 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:21457648 | pubmed:volume | 57 | lld:pubmed |
| pubmed-article:21457648 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21457648 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21457648 | pubmed:pagination | 3-11 | lld:pubmed |
| pubmed-article:21457648 | pubmed:meshHeading | pubmed-meshheading:21457648... | lld:pubmed |
| pubmed-article:21457648 | pubmed:meshHeading | pubmed-meshheading:21457648... | lld:pubmed |
| pubmed-article:21457648 | pubmed:meshHeading | pubmed-meshheading:21457648... | lld:pubmed |
| pubmed-article:21457648 | pubmed:meshHeading | pubmed-meshheading:21457648... | lld:pubmed |
| pubmed-article:21457648 | pubmed:meshHeading | pubmed-meshheading:21457648... | lld:pubmed |
| pubmed-article:21457648 | pubmed:meshHeading | pubmed-meshheading:21457648... | lld:pubmed |
| pubmed-article:21457648 | pubmed:meshHeading | pubmed-meshheading:21457648... | lld:pubmed |
| pubmed-article:21457648 | pubmed:meshHeading | pubmed-meshheading:21457648... | lld:pubmed |
| pubmed-article:21457648 | pubmed:meshHeading | pubmed-meshheading:21457648... | lld:pubmed |
| pubmed-article:21457648 | pubmed:meshHeading | pubmed-meshheading:21457648... | lld:pubmed |
| pubmed-article:21457648 | pubmed:meshHeading | pubmed-meshheading:21457648... | lld:pubmed |
| pubmed-article:21457648 | pubmed:meshHeading | pubmed-meshheading:21457648... | lld:pubmed |
| pubmed-article:21457648 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21457648 | pubmed:articleTitle | A fraction of MCM 2 proteins remain associated with replication foci during a major part of S phase. | lld:pubmed |
| pubmed-article:21457648 | pubmed:affiliation | Max Delbrück Center for Molecular Medicine, Berlin, Germany. | lld:pubmed |
| pubmed-article:21457648 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21457648 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:4171 | entrezgene:pubmed | pubmed-article:21457648 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21457648 | lld:entrezgene |
