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pubmed-article:21455197pubmed:dateCreated2011-4-1lld:pubmed
pubmed-article:21455197pubmed:abstractTextFollicular thyroid carcinoma is being diagnosed less and less frequently despite the increasing incidence of well-differentiated thyroid carcinomas everywhere. This review will discuss the reasons underlying such an observation focusing on the evolution of the morphological and immunohistochemical diagnostic criteria of follicular thyroid tumors. It will address the differential diagnosis between follicular carcinoma and three tumor types--follicular adenoma, follicular variant of papillary carcinoma and poorly differentiated carcinoma--as well as the problems raised by the newly described categories of follicular tumors: follicular tumor of uncertain malignant potential, well-differentiated tumor of uncertain malignant potential and well-differentiated carcinoma, not otherwise specified. Finally, the prognostic and therapeutic significance of some promising molecular biomarkers will be discussed within the frame of the aforementioned histopathological classification.lld:pubmed
pubmed-article:21455197pubmed:languageenglld:pubmed
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pubmed-article:21455197pubmed:statusMEDLINElld:pubmed
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pubmed-article:21455197pubmed:issn1530-0285lld:pubmed
pubmed-article:21455197pubmed:authorpubmed-author:Sobrinho-Simõ...lld:pubmed
pubmed-article:21455197pubmed:authorpubmed-author:MagalhãesJoão...lld:pubmed
pubmed-article:21455197pubmed:authorpubmed-author:AmaroTeresina...lld:pubmed
pubmed-article:21455197pubmed:authorpubmed-author:EloyCatarinaClld:pubmed
pubmed-article:21455197pubmed:authorpubmed-author:LoboCláudiaClld:pubmed
pubmed-article:21455197pubmed:issnTypeElectroniclld:pubmed
pubmed-article:21455197pubmed:volume24 Suppl 2lld:pubmed
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pubmed-article:21455197pubmed:paginationS10-8lld:pubmed
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pubmed-article:21455197pubmed:year2011lld:pubmed
pubmed-article:21455197pubmed:articleTitleFollicular thyroid carcinoma.lld:pubmed
pubmed-article:21455197pubmed:affiliationInstitute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), Porto, Portugal. ssimoes@ipatimup.ptlld:pubmed
pubmed-article:21455197pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21455197pubmed:publicationTypeReviewlld:pubmed
pubmed-article:21455197pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed