| pubmed-article:21454690 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21454690 | lifeskim:mentions | umls-concept:C0007603 | lld:lifeskim |
| pubmed-article:21454690 | lifeskim:mentions | umls-concept:C1420175 | lld:lifeskim |
| pubmed-article:21454690 | lifeskim:mentions | umls-concept:C1426056 | lld:lifeskim |
| pubmed-article:21454690 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:21454690 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:21454690 | lifeskim:mentions | umls-concept:C1326474 | lld:lifeskim |
| pubmed-article:21454690 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:21454690 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:21454690 | lifeskim:mentions | umls-concept:C2827421 | lld:lifeskim |
| pubmed-article:21454690 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:21454690 | pubmed:dateCreated | 2011-5-9 | lld:pubmed |
| pubmed-article:21454690 | pubmed:abstractText | AS160 (TBC1D4) is a known Akt substrate that is phosphorylated downstream of insulin action and that leads to regulated traffic of GLUT4. As GLUT4 vesicle fusion with the plasma membrane is a highly regulated step in GLUT4 traffic, we investigated whether AS160 and 14-3-3 interactions are involved in this process. Fusion was inhibited by a human truncated AS160 variant that encompasses the first N-terminal phosphotyrosine-binding (PTB) domain, by either of the two N-terminal PTB domains, and by a tandem construct of both PTB domains of rat AS160. We also found that in vitro GLUT4 vesicle fusion was strongly inhibited by the 14-3-3-quenching inhibitors R18 and fusicoccin. To investigate the mode of interaction of AS160 and 14-3-3, we examined insulin-dependent increases in the levels of these proteins on GLUT4 vesicles. 14-3-3? was enriched on insulin-stimulated vesicles, and its binding to AS160 on GLUT4 vesicles was inhibited by the AS160 tandem PTB domain construct. These data suggest a model for PTB domain action on GLUT4 vesicle fusion in which these constructs inhibit insulin-stimulated 14-3-3? interaction with AS160 rather than AS160 phosphorylation. | lld:pubmed |
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| pubmed-article:21454690 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21454690 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21454690 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:21454690 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21454690 | pubmed:month | May | lld:pubmed |
| pubmed-article:21454690 | pubmed:issn | 1083-351X | lld:pubmed |
| pubmed-article:21454690 | pubmed:author | pubmed-author:HolmanGeoffre... | lld:pubmed |
| pubmed-article:21454690 | pubmed:author | pubmed-author:KoumanovFranç... | lld:pubmed |
| pubmed-article:21454690 | pubmed:author | pubmed-author:RichardsonJud... | lld:pubmed |
| pubmed-article:21454690 | pubmed:author | pubmed-author:MurrowBeverle... | lld:pubmed |
| pubmed-article:21454690 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21454690 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:21454690 | pubmed:volume | 286 | lld:pubmed |
| pubmed-article:21454690 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21454690 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21454690 | pubmed:pagination | 16574-82 | lld:pubmed |
| pubmed-article:21454690 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:21454690 | pubmed:meshHeading | pubmed-meshheading:21454690... | lld:pubmed |
| pubmed-article:21454690 | pubmed:meshHeading | pubmed-meshheading:21454690... | lld:pubmed |
| pubmed-article:21454690 | pubmed:meshHeading | pubmed-meshheading:21454690... | lld:pubmed |
| pubmed-article:21454690 | pubmed:meshHeading | pubmed-meshheading:21454690... | lld:pubmed |
| pubmed-article:21454690 | pubmed:meshHeading | pubmed-meshheading:21454690... | lld:pubmed |
| pubmed-article:21454690 | pubmed:meshHeading | pubmed-meshheading:21454690... | lld:pubmed |
| pubmed-article:21454690 | pubmed:meshHeading | pubmed-meshheading:21454690... | lld:pubmed |
| pubmed-article:21454690 | pubmed:meshHeading | pubmed-meshheading:21454690... | lld:pubmed |
| pubmed-article:21454690 | pubmed:meshHeading | pubmed-meshheading:21454690... | lld:pubmed |
| pubmed-article:21454690 | pubmed:meshHeading | pubmed-meshheading:21454690... | lld:pubmed |
| pubmed-article:21454690 | pubmed:meshHeading | pubmed-meshheading:21454690... | lld:pubmed |
| pubmed-article:21454690 | pubmed:meshHeading | pubmed-meshheading:21454690... | lld:pubmed |
| pubmed-article:21454690 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21454690 | pubmed:articleTitle | AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane. | lld:pubmed |
| pubmed-article:21454690 | pubmed:affiliation | Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom. | lld:pubmed |
| pubmed-article:21454690 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21454690 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
