| pubmed-article:2145360 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2145360 | lifeskim:mentions | umls-concept:C0004611 | lld:lifeskim |
| pubmed-article:2145360 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2145360 | lifeskim:mentions | umls-concept:C0221284 | lld:lifeskim |
| pubmed-article:2145360 | lifeskim:mentions | umls-concept:C0024348 | lld:lifeskim |
| pubmed-article:2145360 | lifeskim:mentions | umls-concept:C1823153 | lld:lifeskim |
| pubmed-article:2145360 | lifeskim:mentions | umls-concept:C2754073 | lld:lifeskim |
| pubmed-article:2145360 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:2145360 | lifeskim:mentions | umls-concept:C0439097 | lld:lifeskim |
| pubmed-article:2145360 | lifeskim:mentions | umls-concept:C2349976 | lld:lifeskim |
| pubmed-article:2145360 | lifeskim:mentions | umls-concept:C1552644 | lld:lifeskim |
| pubmed-article:2145360 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:2145360 | lifeskim:mentions | umls-concept:C1547348 | lld:lifeskim |
| pubmed-article:2145360 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:2145360 | pubmed:dateCreated | 1990-11-8 | lld:pubmed |
| pubmed-article:2145360 | pubmed:abstractText | Peripheral blood T lymphocytes from healthy donors were stimulated with Mycobacterium tuberculosis in vitro and afterward analyzed phenotypically. Marked expansion of the gamma/delta T cell population (3- to 21-fold) was observed in 15/21 donors 7 to 10 days after stimulation. In addition to M. tuberculosis, Mycobacterium leprae (six of eight) as well as the gram-positive bacteria, Staphylococcus aureus (two of six), group A streptococci (seven of nine), and Listeria monocytogenes (four of eight) augmented gamma/delta TCR expression in peripheral blood T cells of many donors. gamma/delta T lymphocytes expressed IL-2R and secreted IL-2 upon restimulation with M. tuberculosis. Stimulation with M. tuberculosis evoked specific cytolytic activities in gamma/delta T lymphocytes because: gamma/delta T cells lysed M. tuberculosis pulsed but not unpulsed targets; high concentrations of TCR delta 1 mAb facilitated killing of unpulsed target cells; and low doses of anti-TCR delta 1 mAb blocked killing of pulsed targets. Furthermore, gamma/delta T cells from four donors, after activation with M. tuberculosis or with group A streptococci, respectively, only lysed targets pulsed with the homologous agents, whereas in other donors some cross-reactivity was observed. We conclude that, upon contact with mycobacteria and perhaps other microorganisms, gamma/delta T cells are activated which contribute to immunity against infection via IL-2 secretion and specific target cell lysis. | lld:pubmed |
| pubmed-article:2145360 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2145360 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2145360 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:2145360 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2145360 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2145360 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:2145360 | pubmed:author | pubmed-author:KaufmannS HSH | lld:pubmed |
| pubmed-article:2145360 | pubmed:author | pubmed-author:MunkM EME | lld:pubmed |
| pubmed-article:2145360 | pubmed:author | pubmed-author:GatrillA JAJ | lld:pubmed |
| pubmed-article:2145360 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2145360 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2145360 | pubmed:volume | 145 | lld:pubmed |
| pubmed-article:2145360 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2145360 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2145360 | pubmed:pagination | 2434-9 | lld:pubmed |
| pubmed-article:2145360 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2145360 | pubmed:meshHeading | pubmed-meshheading:2145360-... | lld:pubmed |
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| pubmed-article:2145360 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2145360 | pubmed:articleTitle | Target cell lysis and IL-2 secretion by gamma/delta T lymphocytes after activation with bacteria. | lld:pubmed |
| pubmed-article:2145360 | pubmed:affiliation | Department of Medical Microbiology and Immunology, University of Ulm, FRG. | lld:pubmed |
| pubmed-article:2145360 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2145360 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2145360 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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