| pubmed-article:21450329 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21450329 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:21450329 | lifeskim:mentions | umls-concept:C0079744 | lld:lifeskim |
| pubmed-article:21450329 | lifeskim:mentions | umls-concept:C1333602 | lld:lifeskim |
| pubmed-article:21450329 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:21450329 | lifeskim:mentions | umls-concept:C1412785 | lld:lifeskim |
| pubmed-article:21450329 | lifeskim:mentions | umls-concept:C0681842 | lld:lifeskim |
| pubmed-article:21450329 | lifeskim:mentions | umls-concept:C0332293 | lld:lifeskim |
| pubmed-article:21450329 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:21450329 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:21450329 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:21450329 | pubmed:dateCreated | 2011-9-29 | lld:pubmed |
| pubmed-article:21450329 | pubmed:abstractText | Beclin 1 plays a critical role not only in autophagy, but also in apoptosis and differentiation. The prognostic significance of beclin 1 in diffuse large B-cell lymphoma is largely unexplored. Immunohistochemical protein expression of beclin 1 in 118 tumor specimens from patients newly diagnosed with diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone regimen from 2003 to 2007 was analyzed. Beclin 1 expression was observed in 101 (85.6%) patients. Low beclin 1 expression was related to B symptoms (P = .018), advanced Ann Arbor stage (P = .009), International Prognostic Index of 2 or higher (P = .049), elevated serum lactate dehydrogenase level (P = .037), and poor outcome using the revised International Prognostic Index model (P = .013). The complete remission rate after standard treatment was higher in patients with high beclin 1 expression than in those with low beclin 1 expression (77.5% versus 55.3%, P = .013). Beclin 1 expression was inversely associated with bcl-2 expression (P = .019) and positively associated with longer overall survival (P = .035) and progression-free survival (P = .013). In multivariate analysis, beclin 1 expression and the revised International Prognostic Index model independently predicted survival. The proposed clinicopathologic prognostic model including these 2 independent prognostic factors allowed classification of patients into 3 risk groups (P < .0001, respectively). Beclin 1 expression predicts superior clinical outcome in patients with diffuse large B-cell lymphoma treated with standard treatment. The novel prognostic model which divides patients with diffuse large B-cell lymphoma into different risk categories may help guide treatment planning. | lld:pubmed |
| pubmed-article:21450329 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21450329 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21450329 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21450329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21450329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21450329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21450329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21450329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21450329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21450329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21450329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21450329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21450329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21450329 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21450329 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:21450329 | pubmed:issn | 1532-8392 | lld:pubmed |
| pubmed-article:21450329 | pubmed:author | pubmed-author:LiZhi-MingZM | lld:pubmed |
| pubmed-article:21450329 | pubmed:author | pubmed-author:JiangWen-QiWQ | lld:pubmed |
| pubmed-article:21450329 | pubmed:author | pubmed-author:HuangHui-Qian... | lld:pubmed |
| pubmed-article:21450329 | pubmed:author | pubmed-author:LinTong-YuTY | lld:pubmed |
| pubmed-article:21450329 | pubmed:author | pubmed-author:ZhuYing-JieYJ | lld:pubmed |
| pubmed-article:21450329 | pubmed:author | pubmed-author:HuangJia-JiaJ... | lld:pubmed |
| pubmed-article:21450329 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:21450329 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21450329 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:21450329 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21450329 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21450329 | pubmed:pagination | 1459-66 | lld:pubmed |
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| pubmed-article:21450329 | pubmed:meshHeading | pubmed-meshheading:21450329... | lld:pubmed |
| pubmed-article:21450329 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21450329 | pubmed:articleTitle | Beclin 1 expression predicts favorable clinical outcome in patients with diffuse large B-cell lymphoma treated with R-CHOP. | lld:pubmed |
| pubmed-article:21450329 | pubmed:affiliation | State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University, Guangzhou, Guangdong, PR China 510060. | lld:pubmed |
| pubmed-article:21450329 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21450329 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:441925 | entrezgene:pubmed | pubmed-article:21450329 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21450329 | lld:entrezgene |
