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pubmed-article:21444110pubmed:dateCreated2011-7-18lld:pubmed
pubmed-article:21444110pubmed:abstractTextRearrangements in MLL (MLL-r) are common within very young children with leukemia and affect the prognosis and treatment. Previous studies have suggested the use of the NG2 molecule as a marker for MLL-r but these studies were performed using a small number of infants. We analyzed 148 patients (all less than 24 months, 86 less than 12 months) from various centers in Brazil to determine the predictive power of NG2 within that cohort. We show that NG2 can be used for MLL-r prediction; however, proper staff training and standardized sampling procedures are essential when receiving samples from multiple centers as the accuracy of the prediction varies greatly on a per center basis.lld:pubmed
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pubmed-article:21444110pubmed:authorpubmed-author:RenaudGabriel...lld:pubmed
pubmed-article:21444110pubmed:authorpubmed-author:Sant'AnaMaria...lld:pubmed
pubmed-article:21444110pubmed:authorpubmed-author:BarbieriCarol...lld:pubmed
pubmed-article:21444110pubmed:copyrightInfoCopyright © 2011 Elsevier Ltd. All rights reserved.lld:pubmed
pubmed-article:21444110pubmed:issnTypeElectroniclld:pubmed
pubmed-article:21444110pubmed:volume35lld:pubmed
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pubmed-article:21444110pubmed:year2011lld:pubmed
pubmed-article:21444110pubmed:articleTitleChallenges in the use of NG2 antigen as a marker to predict MLL rearrangements in multi-center studies.lld:pubmed
pubmed-article:21444110pubmed:affiliationPediatric Hematology and Oncology Program, Research Center, Instituto Nacional de Câncer, Rio de Janeiro, Brazil.lld:pubmed
pubmed-article:21444110pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21444110pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:21444110pubmed:publicationTypeMulticenter Studylld:pubmed
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