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21441032

Source:http://linkedlifedata.com/resource/pubmed/id/21441032

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pubmed-article:21441032pubmed:abstractTextSome chalcones exert potent anti-inflammatory activities. Mannich bases of heterocyclic chalcones inhibited nitric oxide (NO) production in lipopolysaccharide and interferon-? stimulated RAW 264.7 macrophages. Also Formyl-Met-Leu-Phe and cytochalasin B induced superoxide anion generation (O2·-) and elastase release in human neutrophils. Mannich bases of heterocyclic chalcone analogs exhibited potent inhibitory effects on NO production with IC(50) values ranges between 10.5 and 0.018 ?M, O2·- generation (IC(50) 39.87-0.68 ?M) and elastase release (IC(50) 39.74-0.95 ?M). Compound 29 (IC(50) 0.055 ?M) and 34 (IC(50) 0.018 ?M) were showed excellent inhibition on NO production. On the other hand, compounds 2 and 8 showed potent inhibition on O2·- generation and elastase release. Therefore, these four compounds may be new leads for development of anti-inflammatory activities. The structure-activity relationships are also discussed.lld:pubmed
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pubmed-article:21441032pubmed:copyrightInfoCrown Copyright © 2011. Published by Elsevier Ltd. All rights reserved.lld:pubmed
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pubmed-article:21441032pubmed:articleTitleInhibitory effects of Mannich bases of heterocyclic chalcones on NO production by activated RAW 264.7 macrophages and superoxide anion generation and elastase release by activated human neutrophils.lld:pubmed
pubmed-article:21441032pubmed:affiliationDepartment of Chemistry, National Cheng Kung University, Tainan, Taiwan, ROC.lld:pubmed
pubmed-article:21441032pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21441032pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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