| pubmed-article:21438756 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21438756 | lifeskim:mentions | umls-concept:C0042776 | lld:lifeskim |
| pubmed-article:21438756 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:21438756 | lifeskim:mentions | umls-concept:C0006784 | lld:lifeskim |
| pubmed-article:21438756 | lifeskim:mentions | umls-concept:C0376538 | lld:lifeskim |
| pubmed-article:21438756 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:21438756 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:21438756 | pubmed:dateCreated | 2011-6-2 | lld:pubmed |
| pubmed-article:21438756 | pubmed:abstractText | Porcine reproductive and respiratory syndrome virus nonstructural protein 1 (nsp1) could be auto-cleaved into nsp1? and nsp1?, both of which had the papain-like cysteine protease activities. Previous studies have shown that porcine reproductive and respiratory syndrome virus nsp1 was an interferon (IFN) antagonist. However, the mechanism by which nsp1 inhibited IFN-? production was unclear. Here, we used site-directed mutagenesis that inactivated the papain-like cysteine protease activities of nsp1 to explore whether the papain-like cysteine protease activities were required for nsp1 to disrupt IFN-? production. The results showed that mutations that inactivated papain-like cysteine protease activity of nsp1? made nsp1 lose its IFN antagonism activity, whereas mutations that inactivated papain-like cysteine protease activity of nsp1? did not influence the IFN antagonism activity of nsp1. In conclusion, our present work indicated that the papain-like cysteine protease activity of nsp1? was necessary for nsp1 to inhibit IFN-? induction. | lld:pubmed |
| pubmed-article:21438756 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21438756 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21438756 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21438756 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21438756 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21438756 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21438756 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21438756 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21438756 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21438756 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:21438756 | pubmed:issn | 1557-7430 | lld:pubmed |
| pubmed-article:21438756 | pubmed:author | pubmed-author:WangLiL | lld:pubmed |
| pubmed-article:21438756 | pubmed:author | pubmed-author:LiXuewuX | lld:pubmed |
| pubmed-article:21438756 | pubmed:author | pubmed-author:ZhangGaipingG | lld:pubmed |
| pubmed-article:21438756 | pubmed:author | pubmed-author:WangFangyuF | lld:pubmed |
| pubmed-article:21438756 | pubmed:author | pubmed-author:FanJianmingJ | lld:pubmed |
| pubmed-article:21438756 | pubmed:author | pubmed-author:ShiXibaoX | lld:pubmed |
| pubmed-article:21438756 | pubmed:author | pubmed-author:DengRuiguangR | lld:pubmed |
| pubmed-article:21438756 | pubmed:author | pubmed-author:ZhiYubaoY | lld:pubmed |
| pubmed-article:21438756 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21438756 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:21438756 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21438756 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21438756 | pubmed:pagination | 355-62 | lld:pubmed |
| pubmed-article:21438756 | pubmed:meshHeading | pubmed-meshheading:21438756... | lld:pubmed |
| pubmed-article:21438756 | pubmed:meshHeading | pubmed-meshheading:21438756... | lld:pubmed |
| pubmed-article:21438756 | pubmed:meshHeading | pubmed-meshheading:21438756... | lld:pubmed |
| pubmed-article:21438756 | pubmed:meshHeading | pubmed-meshheading:21438756... | lld:pubmed |
| pubmed-article:21438756 | pubmed:meshHeading | pubmed-meshheading:21438756... | lld:pubmed |
| pubmed-article:21438756 | pubmed:meshHeading | pubmed-meshheading:21438756... | lld:pubmed |
| pubmed-article:21438756 | pubmed:meshHeading | pubmed-meshheading:21438756... | lld:pubmed |
| pubmed-article:21438756 | pubmed:meshHeading | pubmed-meshheading:21438756... | lld:pubmed |
| pubmed-article:21438756 | pubmed:meshHeading | pubmed-meshheading:21438756... | lld:pubmed |
| pubmed-article:21438756 | pubmed:meshHeading | pubmed-meshheading:21438756... | lld:pubmed |
| pubmed-article:21438756 | pubmed:meshHeading | pubmed-meshheading:21438756... | lld:pubmed |
| pubmed-article:21438756 | pubmed:meshHeading | pubmed-meshheading:21438756... | lld:pubmed |
| pubmed-article:21438756 | pubmed:meshHeading | pubmed-meshheading:21438756... | lld:pubmed |
| pubmed-article:21438756 | pubmed:meshHeading | pubmed-meshheading:21438756... | lld:pubmed |
| pubmed-article:21438756 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21438756 | pubmed:articleTitle | The nonstructural protein 1 papain-like cysteine protease was necessary for porcine reproductive and respiratory syndrome virus nonstructural protein 1 to inhibit interferon-? induction. | lld:pubmed |
| pubmed-article:21438756 | pubmed:affiliation | Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou, China. | lld:pubmed |
| pubmed-article:21438756 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21438756 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:1494884 | entrezgene:pubmed | pubmed-article:21438756 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21438756 | lld:entrezgene |
