| pubmed-article:21431901 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21431901 | lifeskim:mentions | umls-concept:C0025663 | lld:lifeskim |
| pubmed-article:21431901 | lifeskim:mentions | umls-concept:C0205463 | lld:lifeskim |
| pubmed-article:21431901 | lifeskim:mentions | umls-concept:C0470187 | lld:lifeskim |
| pubmed-article:21431901 | lifeskim:mentions | umls-concept:C1167956 | lld:lifeskim |
| pubmed-article:21431901 | lifeskim:mentions | umls-concept:C0814812 | lld:lifeskim |
| pubmed-article:21431901 | lifeskim:mentions | umls-concept:C0205421 | lld:lifeskim |
| pubmed-article:21431901 | lifeskim:mentions | umls-concept:C2698650 | lld:lifeskim |
| pubmed-article:21431901 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:21431901 | pubmed:dateCreated | 2011-4-12 | lld:pubmed |
| pubmed-article:21431901 | pubmed:abstractText | In this review, the physiological rationale for atrioventricular and interventricular delay optimization of cardiac resynchronization therapy is discussed including the influence of exercise and long-term cardiac resynchronization therapy. The broad spectrum of both invasive and non-invasive optimization methods is reviewed with critical appraisal of the literature. Although the spectrum of both invasive and non-invasive optimization methods is broad, no single method can be recommend for standard practice as large-scale studies using hard endpoints are lacking. Current efforts mainly investigate optimization during resting conditions; however, there is a need to develop automated algorithms to implement dynamic optimization in order to adapt to physiological alterations during exercise and after anatomical remodeling. | lld:pubmed |
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