| pubmed-article:2142938 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2142938 | lifeskim:mentions | umls-concept:C0014834 | lld:lifeskim |
| pubmed-article:2142938 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:2142938 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:2142938 | lifeskim:mentions | umls-concept:C0204727 | lld:lifeskim |
| pubmed-article:2142938 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:2142938 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:2142938 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:2142938 | lifeskim:mentions | umls-concept:C0002085 | lld:lifeskim |
| pubmed-article:2142938 | lifeskim:mentions | umls-concept:C1823119 | lld:lifeskim |
| pubmed-article:2142938 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:2142938 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:2142938 | pubmed:dateCreated | 1990-8-31 | lld:pubmed |
| pubmed-article:2142938 | pubmed:abstractText | Mutations in several dna genes of Escherichia coli, when introduced into a strain with a lac fusion in the SOS gene sulA, resulted in formation of blue colonies on plates containing 5-bromo-4-chloro-3-indolyl-beta-D-galactoside (X-Gal). Unexpectedly, several lines of evidence indicated that the blue colony color was not primarily due to induction of the SOS system but rather was due to a membrane defect, along with the replication defect, making the cell X-Gal extrasensitive (phenotypically Xgx), possibly because of enhanced permeability to X-Gal or leakage of beta-galactosidase. (i) In most cases, beta-galactosidase specific activity increased only two- to threefold. (ii) Mutations conferring tolerance to colicin E1 resulted in blue colony color with no increase in beta-galactosidase specific activity. (iii) Mutations in either the dnaA, dnaB, dnaC, dnaE, dnaG, or ssb gene, when introduced into a strain containing a bioA::lac fusion, produced a blue colony color without an increase in beta-galactosidase synthesis. These lac fusion strains can serve as signal strains to detect dna mutations as well as membrane mutations. By localized mutagenesis of the 92-min region of the chromosome of the sulA::lac signal strain and picking blue colonies, we isolated a novel ssb allele that confers the same extreme UV sensitivity as a delta recA allele, which is a considerably greater sensitivity than that conferred by the two well-studied ssb alleles, ssb-1 and ssb-113. The technique also yielded dnaB mutants; fortuitously, uvrA mutants were also found. | lld:pubmed |
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| pubmed-article:2142938 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2142938 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2142938 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2142938 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2142938 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2142938 | pubmed:issn | 0021-9193 | lld:pubmed |
| pubmed-article:2142938 | pubmed:author | pubmed-author:TessmanE SES | lld:pubmed |
| pubmed-article:2142938 | pubmed:author | pubmed-author:Schmellik-San... | lld:pubmed |
| pubmed-article:2142938 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2142938 | pubmed:volume | 172 | lld:pubmed |
| pubmed-article:2142938 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2142938 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2142938 | pubmed:pagination | 4378-85 | lld:pubmed |
| pubmed-article:2142938 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2142938 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2142938 | pubmed:articleTitle | Signal strains that can detect certain DNA replication and membrane mutants of Escherichia coli: isolation of a new ssb allele, ssb-3. | lld:pubmed |
| pubmed-article:2142938 | pubmed:affiliation | Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907. | lld:pubmed |
| pubmed-article:2142938 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2142938 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2142938 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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