| pubmed-article:21422150 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21422150 | lifeskim:mentions | umls-concept:C0599757 | lld:lifeskim |
| pubmed-article:21422150 | lifeskim:mentions | umls-concept:C0031272 | lld:lifeskim |
| pubmed-article:21422150 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:21422150 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:21422150 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:21422150 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:21422150 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:21422150 | pubmed:dateCreated | 2011-3-30 | lld:pubmed |
| pubmed-article:21422150 | pubmed:abstractText | M cells are responsible for uptake of mucosal antigens in Peyer's patches (PPs). Differentiation of M cells is thought to be induced by interactions between follicle-associated epithelium and PP cells; however, it remains elusive what types of immune cells function as M-cell inducers. Here, we attempted to identify the cells that serve as an M-cell inducer in PP. We found that a unique B-cell subset characterized by CCR6(hi)CD11c(int) resided in the subepithelial dome (SED) in mouse PP. CCR6(hi)CD11c(int) B cells showed chemotactic migration in response to CCL20. Furthermore, this unique B-cell subset substantially decreased in PP of CCR6-deficient mice, indicating that the SED localization of CCR6(hi)CD11c(int) B cells is most likely regulated by the CCL20-CCR6 system. Concomitantly, CCR6 deficiency caused remarkable decrement of M cells. Moreover, adoptive transfer of CCR6(hi)CD11c(int) B cells from wild-type mice restored the M-cell decrement in CCR6-deficient mice. Collectively, the spatial regulation of CCR6(hi)CD11c(int) B cells via the CCL20-CCR6 system may play a vital role in M-cell differentiation in mice. | lld:pubmed |
| pubmed-article:21422150 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21422150 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21422150 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21422150 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21422150 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21422150 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21422150 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21422150 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21422150 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21422150 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21422150 | pubmed:issn | 1460-2377 | lld:pubmed |
| pubmed-article:21422150 | pubmed:author | pubmed-author:WilliamsIfor... | lld:pubmed |
| pubmed-article:21422150 | pubmed:author | pubmed-author:OhnoHiroshiH | lld:pubmed |
| pubmed-article:21422150 | pubmed:author | pubmed-author:HaseKojiK | lld:pubmed |
| pubmed-article:21422150 | pubmed:author | pubmed-author:KitamuraHiros... | lld:pubmed |
| pubmed-article:21422150 | pubmed:author | pubmed-author:TakahashiDais... | lld:pubmed |
| pubmed-article:21422150 | pubmed:author | pubmed-author:EbisawaMasash... | lld:pubmed |
| pubmed-article:21422150 | pubmed:author | pubmed-author:KnoopKathryn... | lld:pubmed |
| pubmed-article:21422150 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21422150 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:21422150 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21422150 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21422150 | pubmed:pagination | 261-9 | lld:pubmed |
| pubmed-article:21422150 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
| pubmed-article:21422150 | pubmed:meshHeading | pubmed-meshheading:21422150... | lld:pubmed |
| pubmed-article:21422150 | pubmed:meshHeading | pubmed-meshheading:21422150... | lld:pubmed |
| pubmed-article:21422150 | pubmed:meshHeading | pubmed-meshheading:21422150... | lld:pubmed |
| pubmed-article:21422150 | pubmed:meshHeading | pubmed-meshheading:21422150... | lld:pubmed |
| pubmed-article:21422150 | pubmed:meshHeading | pubmed-meshheading:21422150... | lld:pubmed |
| pubmed-article:21422150 | pubmed:meshHeading | pubmed-meshheading:21422150... | lld:pubmed |
| pubmed-article:21422150 | pubmed:meshHeading | pubmed-meshheading:21422150... | lld:pubmed |
| pubmed-article:21422150 | pubmed:meshHeading | pubmed-meshheading:21422150... | lld:pubmed |
| pubmed-article:21422150 | pubmed:meshHeading | pubmed-meshheading:21422150... | lld:pubmed |
| pubmed-article:21422150 | pubmed:meshHeading | pubmed-meshheading:21422150... | lld:pubmed |
| pubmed-article:21422150 | pubmed:meshHeading | pubmed-meshheading:21422150... | lld:pubmed |
| pubmed-article:21422150 | pubmed:meshHeading | pubmed-meshheading:21422150... | lld:pubmed |
| pubmed-article:21422150 | pubmed:meshHeading | pubmed-meshheading:21422150... | lld:pubmed |
| pubmed-article:21422150 | pubmed:meshHeading | pubmed-meshheading:21422150... | lld:pubmed |
| pubmed-article:21422150 | pubmed:meshHeading | pubmed-meshheading:21422150... | lld:pubmed |
| pubmed-article:21422150 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21422150 | pubmed:articleTitle | CCR6hiCD11c(int) B cells promote M-cell differentiation in Peyer's patch. | lld:pubmed |
| pubmed-article:21422150 | pubmed:affiliation | Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Yokohama, Kanagawa 230-0045, Japan. | lld:pubmed |
| pubmed-article:21422150 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21422150 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:12458 | entrezgene:pubmed | pubmed-article:21422150 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21422150 | lld:entrezgene |
