| pubmed-article:2141741 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2141741 | lifeskim:mentions | umls-concept:C0003062 | lld:lifeskim |
| pubmed-article:2141741 | lifeskim:mentions | umls-concept:C0039011 | lld:lifeskim |
| pubmed-article:2141741 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:2141741 | lifeskim:mentions | umls-concept:C0450127 | lld:lifeskim |
| pubmed-article:2141741 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:2141741 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:2141741 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:2141741 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:2141741 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:2141741 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:2141741 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:2141741 | lifeskim:mentions | umls-concept:C0522536 | lld:lifeskim |
| pubmed-article:2141741 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:2141741 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2141741 | pubmed:dateCreated | 1990-7-31 | lld:pubmed |
| pubmed-article:2141741 | pubmed:abstractText | Previous studies utilizing a recombinant MHC haplo-type in our partially inbred miniature swine herd have demonstrated that some recipients matched only for SLA class II show long-term acceptance of renal allografts without exogenous immunosuppression. Such animals have been shown to develop systemic tolerance as evidenced by prolonged rejection times of subsequent donor-specific, but not third-party, skin grafts. In the present studies in vitro cellular responses of long-term tolerant animals and of 7 animals studied sequentially are presented. Long-term tolerant animals demonstrated responses consistent with the absence of the class I reactive helper populations normally present in naive controls. Animals studied sequentially segregated into two groups based on cellular reactivity and survival. All animals showed complete loss of antidonor class I cell-mediated lymphocytolytic (CML) reactivity by postoperative day 10. However, animals surviving less than 20 days maintained CML reactivity to donor class I plus third-party class II in the posttransplant period, while animals surviving greater than 40 days lost such reactivity. Addition of exogenous interleukin 2 could not reverse this loss. These studies suggest that tolerance induction to a renal allograft across a class I only difference involves effects on both helper and killer class I reactive cell populations. | lld:pubmed |
| pubmed-article:2141741 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2141741 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2141741 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2141741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2141741 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2141741 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2141741 | pubmed:issn | 0041-1337 | lld:pubmed |
| pubmed-article:2141741 | pubmed:author | pubmed-author:SuzukiTT | lld:pubmed |
| pubmed-article:2141741 | pubmed:author | pubmed-author:SakamotoKK | lld:pubmed |
| pubmed-article:2141741 | pubmed:author | pubmed-author:SachsD HDH | lld:pubmed |
| pubmed-article:2141741 | pubmed:author | pubmed-author:LunneyJ KJK | lld:pubmed |
| pubmed-article:2141741 | pubmed:author | pubmed-author:GuzzettaP CPC | lld:pubmed |
| pubmed-article:2141741 | pubmed:author | pubmed-author:ChesterC HCH | lld:pubmed |
| pubmed-article:2141741 | pubmed:author | pubmed-author:KortzE OEO | lld:pubmed |
| pubmed-article:2141741 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2141741 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:2141741 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2141741 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2141741 | pubmed:pagination | 1142-9 | lld:pubmed |
| pubmed-article:2141741 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:2141741 | pubmed:meshHeading | pubmed-meshheading:2141741-... | lld:pubmed |
| pubmed-article:2141741 | pubmed:meshHeading | pubmed-meshheading:2141741-... | lld:pubmed |
| pubmed-article:2141741 | pubmed:meshHeading | pubmed-meshheading:2141741-... | lld:pubmed |
| pubmed-article:2141741 | pubmed:meshHeading | pubmed-meshheading:2141741-... | lld:pubmed |
| pubmed-article:2141741 | pubmed:meshHeading | pubmed-meshheading:2141741-... | lld:pubmed |
| pubmed-article:2141741 | pubmed:meshHeading | pubmed-meshheading:2141741-... | lld:pubmed |
| pubmed-article:2141741 | pubmed:meshHeading | pubmed-meshheading:2141741-... | lld:pubmed |
| pubmed-article:2141741 | pubmed:meshHeading | pubmed-meshheading:2141741-... | lld:pubmed |
| pubmed-article:2141741 | pubmed:meshHeading | pubmed-meshheading:2141741-... | lld:pubmed |
| pubmed-article:2141741 | pubmed:meshHeading | pubmed-meshheading:2141741-... | lld:pubmed |
| pubmed-article:2141741 | pubmed:meshHeading | pubmed-meshheading:2141741-... | lld:pubmed |
| pubmed-article:2141741 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2141741 | pubmed:articleTitle | Mechanism of tolerance following class I--disparate renal allografts in miniature swine. Cellular responses of tolerant animals. | lld:pubmed |
| pubmed-article:2141741 | pubmed:affiliation | Immunology Branch, National Cancer Institute of Health, Bethesda, Maryland 20892. | lld:pubmed |
| pubmed-article:2141741 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2141741 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2141741 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2141741 | lld:pubmed |
