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pubmed-article:21407961pubmed:dateCreated2011-3-16lld:pubmed
pubmed-article:21407961pubmed:abstractTextIn a double-blind, prospective study, 40 patients diagnosed with DSM-IV generalized anxiety disorder and stabilized on alprazolam therapy were randomized to receive the same dose of either conventional or sustained-released alprazolam for two weeks, followed by the other formulation of alprazolam in an identical dose for a further two weeks. Conventional alprazolam was administered thrice daily while the sustained-release formulation was administered once-daily, in the morning. Thirty four patients completed the study. Recruitment into the study was associated with a significant decrease in all measures of illness severity; however, no efficacy differences between the two forms of alprazolam were observed. Adverse effects, specifically insomnia, were reported more with the sustained-release formulation. It is concluded that once-daily sustained-release alprazolam is as effective as the conventional form of the drug, and may be preferable because of a wide range of advantages; in this study, the higher incidence of adverse effects with the sustained-release drug was probably an artefact of the experimental design, which fostered a (nighttime) state of partial drug withdrawal.lld:pubmed
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pubmed-article:21407961pubmed:pagination302-7lld:pubmed
pubmed-article:21407961pubmed:dateRevised2011-7-27lld:pubmed
pubmed-article:21407961pubmed:year2000lld:pubmed
pubmed-article:21407961pubmed:articleTitleA double-blind, controlled evaluation of the efficacy and adverse effect profile of sustained-release alprazolam.lld:pubmed
pubmed-article:21407961pubmed:affiliationCHITTARANJAN ANDRADE, MD., Additional Professor & Head, Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore-560 029.lld:pubmed
pubmed-article:21407961pubmed:publicationTypeJournal Articlelld:pubmed
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