| pubmed-article:21402741 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21402741 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:21402741 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:21402741 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:21402741 | lifeskim:mentions | umls-concept:C0531372 | lld:lifeskim |
| pubmed-article:21402741 | lifeskim:mentions | umls-concept:C0546816 | lld:lifeskim |
| pubmed-article:21402741 | lifeskim:mentions | umls-concept:C1420808 | lld:lifeskim |
| pubmed-article:21402741 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:21402741 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:21402741 | pubmed:dateCreated | 2011-4-12 | lld:pubmed |
| pubmed-article:21402741 | pubmed:abstractText | Memory T helper cells (Th cells) play an important role in host defense against pathogens but also contribute to the pathogenesis of inflammatory disorders. We found that a soluble decoy lymphotoxin ? receptor (LT-?R)-Fc, which can block tumor necrosis factor (TNF)-related ligands LIGHT (TNFSF14) and LT-?? binding to the herpesvirus entry mediator (HVEM) and the LT-?R, inhibited the accumulation of memory Th2 cells after antigen encounter and correspondingly reduced inflammatory responses in vivo. Showing that this was a function of the receptor for LIGHT, antigen-specific memory CD4 T cells deficient in HVEM were also unable to persist, despite having a normal immediate response to recall antigen. HVEM(-/-) memory Th2 cells displayed reduced activity of PKB (protein kinase B; Akt), and constitutively active Akt rescued their survival and restored strong inflammation after antigen rechallenge. This was not restricted to Th2 memory cells as HVEM-deficient Th1 memory cells were also impaired in surviving after encounter with recall antigen. Furthermore, the absence of LIGHT on T cells recapitulated the defect seen with the absence of HVEM, suggesting that activated T cells communicate through LIGHT-HVEM interactions. Collectively, our results demonstrate a critical role of HVEM signals in the persistence of large pools of memory CD4 T cells. | lld:pubmed |
| pubmed-article:21402741 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21402741 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21402741 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21402741 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21402741 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21402741 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21402741 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21402741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21402741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21402741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21402741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21402741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21402741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21402741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21402741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21402741 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21402741 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21402741 | pubmed:issn | 1540-9538 | lld:pubmed |
| pubmed-article:21402741 | pubmed:author | pubmed-author:PfefferKlausK | lld:pubmed |
| pubmed-article:21402741 | pubmed:author | pubmed-author:CroftMichaelM | lld:pubmed |
| pubmed-article:21402741 | pubmed:author | pubmed-author:WareCarlC | lld:pubmed |
| pubmed-article:21402741 | pubmed:author | pubmed-author:ScheuStefanie... | lld:pubmed |
| pubmed-article:21402741 | pubmed:author | pubmed-author:NorrisPaula... | lld:pubmed |
| pubmed-article:21402741 | pubmed:author | pubmed-author:SoTakanoriT | lld:pubmed |
| pubmed-article:21402741 | pubmed:author | pubmed-author:SorooshPejman... | lld:pubmed |
| pubmed-article:21402741 | pubmed:author | pubmed-author:DohertyTaylor... | lld:pubmed |
| pubmed-article:21402741 | pubmed:author | pubmed-author:KhorramNaseem... | lld:pubmed |
| pubmed-article:21402741 | pubmed:author | pubmed-author:MehtaAmit... | lld:pubmed |
| pubmed-article:21402741 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21402741 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:21402741 | pubmed:volume | 208 | lld:pubmed |
| pubmed-article:21402741 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21402741 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21402741 | pubmed:pagination | 797-809 | lld:pubmed |
| pubmed-article:21402741 | pubmed:dateRevised | 2011-10-11 | lld:pubmed |
| pubmed-article:21402741 | pubmed:meshHeading | pubmed-meshheading:21402741... | lld:pubmed |
| pubmed-article:21402741 | pubmed:meshHeading | pubmed-meshheading:21402741... | lld:pubmed |
| pubmed-article:21402741 | pubmed:meshHeading | pubmed-meshheading:21402741... | lld:pubmed |
| pubmed-article:21402741 | pubmed:meshHeading | pubmed-meshheading:21402741... | lld:pubmed |
| pubmed-article:21402741 | pubmed:meshHeading | pubmed-meshheading:21402741... | lld:pubmed |
| pubmed-article:21402741 | pubmed:meshHeading | pubmed-meshheading:21402741... | lld:pubmed |
| pubmed-article:21402741 | pubmed:meshHeading | pubmed-meshheading:21402741... | lld:pubmed |
| pubmed-article:21402741 | pubmed:meshHeading | pubmed-meshheading:21402741... | lld:pubmed |
| pubmed-article:21402741 | pubmed:meshHeading | pubmed-meshheading:21402741... | lld:pubmed |
| pubmed-article:21402741 | pubmed:meshHeading | pubmed-meshheading:21402741... | lld:pubmed |
| pubmed-article:21402741 | pubmed:meshHeading | pubmed-meshheading:21402741... | lld:pubmed |
| pubmed-article:21402741 | pubmed:meshHeading | pubmed-meshheading:21402741... | lld:pubmed |
| pubmed-article:21402741 | pubmed:meshHeading | pubmed-meshheading:21402741... | lld:pubmed |
| pubmed-article:21402741 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21402741 | pubmed:articleTitle | Herpesvirus entry mediator (TNFRSF14) regulates the persistence of T helper memory cell populations. | lld:pubmed |
| pubmed-article:21402741 | pubmed:affiliation | Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA. | lld:pubmed |
| pubmed-article:21402741 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21402741 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:17000 | entrezgene:pubmed | pubmed-article:21402741 | lld:entrezgene |
| entrez-gene:50930 | entrezgene:pubmed | pubmed-article:21402741 | lld:entrezgene |
| entrez-gene:230979 | entrezgene:pubmed | pubmed-article:21402741 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21402741 | lld:entrezgene |
