| pubmed-article:2138649 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2138649 | lifeskim:mentions | umls-concept:C0085289 | lld:lifeskim |
| pubmed-article:2138649 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:2138649 | lifeskim:mentions | umls-concept:C0205169 | lld:lifeskim |
| pubmed-article:2138649 | lifeskim:mentions | umls-concept:C0796344 | lld:lifeskim |
| pubmed-article:2138649 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:2138649 | lifeskim:mentions | umls-concept:C0449450 | lld:lifeskim |
| pubmed-article:2138649 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:2138649 | pubmed:dateCreated | 1990-4-30 | lld:pubmed |
| pubmed-article:2138649 | pubmed:abstractText | Analysis of the capacity of splenocytes from non-prototypic Mlsa or Mlsc mouse strains to stimulate allogeneic H-2k-compatible T cells in a primary Mls-defined MLR provided interesting examples of exceptions to the usually stated characterization of Mlsa and Mlsc determinants as highly stimulatory of weakly stimulatory, respectively. Across the Mlsa barrier, MA/My stimulator cells had a significantly reduced capacity to elicit responder proliferation in comparison with prototypic AKR/J or less well studied C58/J, CE/J, or RF/J splenocytes. Across the Mlsc barrier, a gradient of stimulatory ability was observed with RF/J splenocytes being virtually nonstimulatory, prototypic C3H/HeJ splenocytes having an intermediate capacity, and CE/J and C58/J being highly stimulatory presenters of this non-MHC specificity. The differing capacity of each of these H-2k stimulator cells to elicit unprimed responder cell proliferation across an Mlsa or Mlsc difference correlated with the T cell growth factor activity that was secreted into the MLR supernatants. The super stimulatory form of Mlsc was expressed in an autosomal dominant fashion by (Mlsc poorly stimulatory x Mlsc super-stimulatory)F1 animals, (BALB.K x C58/J)F1 or (RF/J x CE/J)F1. The segregation of Mlsc stimulatory ability among first backcross and F2 animals derived from the former F1 was compatible with a single non-MHC gene controlling the expression and presentation of the super-stimulatory form of Mlsc. The regulatory nature of this gene was indicated by the observation that F1 animals generated from the Mlsc nonprototypic and poorly stimulatory BALB/c parental strain were self-tolerant to the super-stimulatory form of Mlsc. The existence of an Mls specificity other than a and c was suggested by positive non-MHC MLR responses in certain responder/stimulator cell combinations of Mls prototypic and nonprototypic mouse strains. | lld:pubmed |
| pubmed-article:2138649 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2138649 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2138649 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2138649 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2138649 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2138649 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2138649 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2138649 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2138649 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2138649 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2138649 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:2138649 | pubmed:author | pubmed-author:RyanJ JJJ | lld:pubmed |
| pubmed-article:2138649 | pubmed:author | pubmed-author:MondJ JJJ | lld:pubmed |
| pubmed-article:2138649 | pubmed:author | pubmed-author:FinkelmanF... | lld:pubmed |
| pubmed-article:2138649 | pubmed:author | pubmed-author:LeJeuneH BHB | lld:pubmed |
| pubmed-article:2138649 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2138649 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2138649 | pubmed:volume | 144 | lld:pubmed |
| pubmed-article:2138649 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2138649 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2138649 | pubmed:pagination | 2506-17 | lld:pubmed |
| pubmed-article:2138649 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2138649 | pubmed:meshHeading | pubmed-meshheading:2138649-... | lld:pubmed |
| pubmed-article:2138649 | pubmed:meshHeading | pubmed-meshheading:2138649-... | lld:pubmed |
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| pubmed-article:2138649 | pubmed:meshHeading | pubmed-meshheading:2138649-... | lld:pubmed |
| pubmed-article:2138649 | pubmed:meshHeading | pubmed-meshheading:2138649-... | lld:pubmed |
| pubmed-article:2138649 | pubmed:meshHeading | pubmed-meshheading:2138649-... | lld:pubmed |
| pubmed-article:2138649 | pubmed:meshHeading | pubmed-meshheading:2138649-... | lld:pubmed |
| pubmed-article:2138649 | pubmed:meshHeading | pubmed-meshheading:2138649-... | lld:pubmed |
| pubmed-article:2138649 | pubmed:meshHeading | pubmed-meshheading:2138649-... | lld:pubmed |
| pubmed-article:2138649 | pubmed:meshHeading | pubmed-meshheading:2138649-... | lld:pubmed |
| pubmed-article:2138649 | pubmed:meshHeading | pubmed-meshheading:2138649-... | lld:pubmed |
| pubmed-article:2138649 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2138649 | pubmed:articleTitle | Genetic analysis of the presentation of minor lymphocyte-stimulating determinants. II. Differing non-MHC control of super-stimulatory and more poorly stimulatory Mls phenotypes. | lld:pubmed |
| pubmed-article:2138649 | pubmed:affiliation | Immunobiology and Transplantation Department, Naval Medical Research Institute, Bethesda, MD 20814-5055. | lld:pubmed |
| pubmed-article:2138649 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2138649 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2138649 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| entrez-gene:111375 | entrezgene:pubmed | pubmed-article:2138649 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2138649 | lld:pubmed |
